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003			OSt
005			20251103105803.0
008			251021s2024 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a546
092			_a546 _221
097			_aM.Sc
099			_aCai01.12.09.M.Sc.2024.Mo.S
100	0		_aMohamed Ahmed Mohamed Abdel Wahab, _epreparation.
245	1	0	_aSynthesis and characterization of modified metal based nano materials and their applications / _cby Mohamed Ahmed Mohamed Abdel Wahab ; Supervisors Prof. Dr. Mohamed A. Zaye, Dr. Ayman S. Eliwa.
246	1	5	_aالتأثير العلاجي للميلاتونين مع / أو الخلايا الجذعية الوسيطة المشتقة من النسيج الدهني على السمية الكبدية الكلوية المستحثة بالدوكسوروبيسين –في جرذان ويستار
264		0	_c2024.
300			_a116 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (M.Sc)-Cairo University, 2024.
504			_aBibliography: pages 97-112.
520		3	_aDoxorubicin (DOX), is highly potent against cancer, but it is limited due to its severe side effects, including hepatotoxicity and renal toxicity. This toxicity is caused by oxidative stress, resulting in biochemical, histological, and genetic abnormalities. The antioxidant activity of Melatonin (MEL) and the regenerative properties of Adipose-derived mesenchymal stem cells (ADMSCs) show a promising strategy against DOX-induced toxicity. This study investigated the therapeutic effects of MEL & ADMSCs against DOX-induced toxicity. The research aimed to find whether the antioxidant properties of MEL, the regenerative capabilities, and the anti-inflammatory effect of ADMSCs could synergistically alleviate the adverse effects of DOX. The study included 2 main groups: a negative control group and a DOX group receiving 6 doses of DOX to induce organ toxicity. Subsequently, rats from both groups were subdivided to receive treatments of saline, MEL, ADMSCs, or a combination of them. Rats were euthanized, then blood and tissue samples were collected. The analysis included the evaluation of histopathological changes, oxidative stress biomarkers, gene expression profiles, and DNA damage. DOX induces oxidative stress, inflammation, and genotoxicity in livers and kidneys while reducing antioxidant enzyme activity. MEL and/or ADMSCs treatments effectively mitigate these effects, suggesting the protective mechanisms involved in apoptosis pathways, evidenced by changes in p53 and Bcl-2 expression levels, as well as assessment of double-stranded breaks using the neutral comet assay, and also improvement of the inflammatory markers IL-6 & IL-10 evidenced by the histopathological changes. MEL and ADMSCs counteract the adverse effects caused by DOX, potentially enhancing chemotherapy safety. The synergistic benefits of combination therapy in improving chemotherapy tolerability allow further investigation in preclinical models to optimize treatment strategies and support efficacy before clinical application.
520		3	_aالهدف من هذه الأطروحة هو تخليق قاعدة شييف كرا بطة عضيوية صيلبة طويلة )رابط( في بنية .MOF دراسات فيزيائية كيميائية على را بطة قاعدة شيف المصنعة باستخدام FT-IR و XRD و 1HNMR وقييا الطيف الكتلي والتحلييل الحراري. أي لضييييا، تخليق أطر عضييييويية معيدنيية يدييدة، Co-MOF من خلال تفاعل أيونات الكوبلت (II) وقاعدة شيف تحت ظروف التفاعل المائي الحراري التقليدية. تم اسييتخدام العديد من أدوات التوصيييف لإلقاء الضييوء على بنية وسييلو MOFs المصيينعة (Co-MOF) مثل FTIR، حيود الأشييييعة السييييينية للمسييييحوق، قياسييييات التحليل الوزني الحراري (TGA)، تحليل (BET) Brunauer-Emmett-Teller، المجهر الإلكتروني الماسيح نبلا للى ن مع تقنييات قييا .EDX تم التحقيق في MOFs المصيييينعية (Co-MOF) كمحفزات كهربيائيية فعيالية للعديد من التطبيقات البيئية مثل تقسيم الماء والأكسدة الكهربائية للميثانول.
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650		0	_aInorganic Chemistry
650		0	_aالكيمياء غير العضوية
653		1	_aMetal-organic framework (MOF) _aElectrochemical oxidation _aWater splitting _aFuel cell, _aX-ray diffraction (XRD) _ascanning electron microscope (SEM) _aenergy dispersive X-ray (EDX)
700	0		_aMohamed A. Zaye _ethesis advisor.
700	0		_aAyman S. Eliwa. _ethesis advisor.
900			_b01-01-2025 _cMohamed A. Zaye _cAyman S. Eliwa _UCairo University _FFaculty of Science _DDepartment of Chemistry
905			_aShimaa _eEman Ghareb
942			_2ddc _cTH _e21 _n0
999			_c175127