000			04753namaa22004571i 4500
003			EG-GICUC
005			20251122111329.0
008			251121s2024 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a572
092			_a572 _221
097			_aPh.D
099			_aCai01.07.04.Ph.D.2024.Ra.B
100	0		_aRania Ahmed Salamma Mahgoub, _epreparation.
245	1	0	_aBiochemical studies on food fortification with some vitamins and minerals for anemia treatment / _cby Rania Ahmed Salamma Mahgoub ; Supervisors Dr. Abdel Kader Moursy Abdel-Samad, Dr.Mohamed Abdel-Moneam Naguib, Dr.Mahmoud Abdel-Haleim Mahmoud, Dr. Hanna Hussein El-Sayed.
246	1	5	_aدراسات كيميائية حيوية على تزويد الغذاء ببعض الفيتامينات والمعادن لعلاج الانيمياء
264		0	_c2024.
300			_a178 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (Ph.D)-Cairo University, 2024.
504			_aBibliography: pages 156-178.
520		3	_aIron deficiency anemia (IDA) represents a critical global health concern. This investigation involves the characterization and evaluation of several nanoparticle formulations—iron oxide magnetic nanoparticles (IONPs), zinc oxide nanoparticles (ZnO-NPs), magnesium oxide nanoparticles (MgO-NPs), and iron folate nanoparticles—as potential treatments for IDA. For the in vivo study, 110 Sprague-Dawley rats (both female and male) were divided into seven groups: a normal group, anemic rats, and four groups treated with various iron formulations. IDA was induced in the rats using an iron-deficient diet, followed by feeding with different iron compounds until their hemoglobin levels reached 12 g/dl. The rats were then placed on a normal diet for two weeks. Biological and hematological parameters were monitored throughout the treatment. Results indicated that all treated groups showed positive outcomes, achieving normal values. Notably, iron folate nanoparticles demonstrated superior bioavailability, with female rats showing 244.23% HRE ratio/day and 19.89% RBV HRE ratio/day, and male rats showing 155.02% HRE ratio/day and 16.63% RBV HRE ratio/day, outperforming other treatments. Histopathological analysis revealed persistent liver tissue damage in anemic rats treated with FeSO4 and IONPs, though FeMgO-NPs and iron folate nanoparticles showed better results. The spleen appeared normal across all repleted groups. These findings suggest that IONPs can enhance iron bioavailability for IDA treatment, though their efficacy is improved when combined with other metals to maximize benefits and reduce side effects
520		3	_aيمثل فقر الدم الناجم عن نقص الحديد مشكلة صحية عالمية بالغة الاهمية. يتضمن هذا البحث توصيف وتقييم بيولوجي للعديد من تركيبات جزيئات أكسيد الحديد النانوية في علاجات فقر الدم الناجم عن نقص الحديد. اشارت النتائج الى ان جميع المجموعات المعالجة حققت قيما طبيعية. والجدير بالذكر ان جزيئات حمض الفوليك النانوية أظهرت توافرا حيويا متفوقا. تشير هذه النتائج الى ان جزيئات أكسيد الحديد النانوية يمكن ان تعزز التوافر الحيوي للحديد لعلاج فقر الدم الناجم عن نقص الحديد وتتحسن فعاليتها عند دمجها مع معادن نانوية وحمض الفوليك كفيتامين لتحقيق اقصى قدر من الفوائد وتقليل الاثار الجانبية.
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650		0	_aBiochemistry
650		0	_aالكيمياء الحيوية
653		1	_airon deficiency anemia _afortification _aIONPs _anano _ametals _afolic acid
700	0		_aAbdel Kader Moursy Abdel-Samad _ethesis advisor.
700	0		_aMohamed Abdel- Moneam Naguib _ethesis advisor.
700	0		_aMahmoud Abdel-Haleim Mahmoud _ethesis advisor.
700	0		_aHanna Hussein El- Sayed _ethesis advisor.
900			_b01-01-2024 _cAbdel Kader Moursy Abdel-Samad _cMohamed Abdel- Moneam Naguib _cMahmoud Abdel-Haleim Mahmoud _cHanna Hussein El-Sayed _UCairo University _FFaculty of Agriculture _DDepartment of Biochemistry
905			_aShimaa
942			_2ddc _cTH _e21 _n0
999			_c176067