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003			EG-GICUC
005			20251214140655.0
008			251214s2025 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a547
092			_a547 _221
097			_aM.Sc
099			_aCai01.12.10.M.Sc.2025.Mo.S
100	0		_aMohamed Saber Mohamed, _epreparation.
245	1	0	_aSynthesis of some novel compounds containing nitrogen and/or sulfur elements via michael and/or hantzsch reactions / _cby Mohamed Saber Mohamed ; Supervisors: Prof. Dr. Ismail Abdelshafy Abdelhamid, Prof. Dr. Amr Mohamed Abdelmoniem, Dr. Moaz Mohamed Abdou.
246	1	5	_aتحضير بعض المركبات الجديدة التى تحتوي على عناصر النتروجين و/أو الكبريت من خلال تفاعلات مايكل و/أو هانتزش
264		0	_c2025.
300			_a124 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (M.Sc)-Cairo University, 2025.
504			_aBibliography: pages 112-118.
520		3	_aIntroduction: 2.5% of adults worldwide suffer from hyperthyroidism, which is associated with osteoporosis, heart disease, and increased mortality. Aim: The current study evaluates the preventive and therapeutic effect of Ovothiol-A on Thyroxine-induced hyperthyroidism in rats. Methods: Experimental animals were split into two categories: protective and curative. Each group was further separated into three subgroups (6 per group): control, hyperthyroidism (HT), and Ovothiol-A (250 mg/kg). Thyroxine hormone (600 mg/kg) is administered orally to rats to induce HT. Results: Ovothiol-A supplementation resulted in significant decreases in organs weight index, triiodothyronine (T3), thyroxine (T4), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, urea, uric acid, creatine kinase (CK-MB), lactate dehydrogenase (LDH), fasting blood sugar (FBS), malondialdehyde (MDA), and nitric oxide (NO) levels, fibrosis, and tumor necrosis factor alpha (TNF-α) while increasing in body weight, Thyroid-stimulating hormone (TSH), lipid profile, total protein (TP), serum albumin, total cholesterol (TC), serum triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoproteins cholesterol (HDL-C), glutathione reduced (GSH), catalase (CAT), glutathione-S-transferase (GST). Histopathological investigation revealed significant improvement in the thyroid gland, liver, kidney, and heart tissues, significantly reducing collagen deposition. The electrocardiogram (ECG) revealed an improvement in ST segment and heart rhythm. Conclusion: Ovothiol-A exhibited protective and therapeutic effects against hyperthyroidism in rats. Ovothiol-A exhibits antithyroid activity by stimulating the antioxidant system, reducing inflammation, and restoring thyroid hormone levels.
520		3	_aاشتملت الدراسة علي تصنيع سلسلة جديدة من المركبات الحلقية غير المتجانسة التي تحتوي على 4و5- ثنائي فينيل-1H-إيميدازول، وبنزوثيازول، و1H-فينانثرو[9و10-d]إيميدازول، وتتراهيدروكرومين، وإيمينوبيران، و4H-بيران هجينة تعتمد على 2-(4-(1-فينيل-1H-بيرازول-3-يل)فينوكسي)-N-أريل أسيتاميدات عبر روابط ذرات غير متجانسة من الكربون-الكربون و باستخدام عمليات التكثيف الحلقي متعدد المكونات وعبر تفاعلات مايكل.
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650		0	_aOrganic Chemistry
650		0	_aكيمياء عضوية
653		1	_ahyperthyroidism _aOvothiol-A _aoxidative stress _athyroid gland _aliver dysfunction _akidney _aheart _ahistopathology _afibrosis _aبيرازول _aديميدون
700	0		_aIsmail Abdelshafy Abdelhamid _ethesis advisor.
700	0		_aAmr Mohamed Abdelmoniem _ethesis advisor.
900			_b01-01-2025 _cIsmail Abdelshafy Abdelhamid _cAmr Mohamed Abdelmoniem _cMoaz Mohamed Abdou _UCairo University _FFaculty of Science _DDepartment of Chemistry
905			_aShimaa
942			_2ddc _cTH _e21 _n0
999			_c176697