000			11086namaa22004451i 4500
003			EG-GICUC
005			20260303103811.0
008			260221s2025 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a616.42
092			_a616.42 _221
097			_aPh.D
099			_aCai01.11.33.Ph.D.2025.Ma.R
100	0		_aMariam Ismail Abdelraouf Ahmed, _epreparation.
245	1	0	_aRole of Grey Scale Transabdominal Ultrasound, Duplex Doppler Ultrasound and Shear Wave Elastography in the Characterization of Endo-abdominal lymphadenopathy compared to histopathological assessment / _cby Mariam Ismail Abdelraouf Ahmed ; Supervisors Prof. Dr. Maha Sayed HasabAllah, Prof. Dr. Hany Mofeed Shehab, Dr. Yasmine Mohamed Gaber.
246	1	5	_aدور الموجات الصوتية عبر البطن و الموجات فوق الصوتية المزدوجة و الدوبلر و تصوير المرونة بموجة القص فى توصيف امراض الغدد الليمفاوية المختلفة و مقارنتة بفحص الانسجة
264		0	_c2025.
300			_a109 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (Ph.D)-Cairo University, 2025.
504			_aBibliography: pages 83 -107.
520		3	_aBackground: Differentiating benign from malignant lymph nodes (LNs) is considered a clinical dilemma, necessitating histopathological diagnosis in most cases. Shear wave elastography (SWE), which assesses tissue stiffness, adds to the diagnostic power of ultrasound (US). Aim: to determine the role of transabdominal US, Doppler examination, and SWE in characterizing endo-abdominal LNs of different etiologies. Patients and methods: This cross-sectional study included 75 patients with intra- abdominal LNs with confirmed histopathological diagnosis. Demographic, clinical, and laboratory findings were analyzed. US features for characterization of LNs were evaluated, including the LNs' size, shape, echogenicity, and Doppler density. Elasticity estimates were color-coded to generate a quantitative SWE image for stiffness (kPa) and velocity (m/sec). The mean value of 3 consecutive measurements in the same LN was used for statistical analysis. Results: Among the patients included, 50 (66.6%) had inflammatory LNs (32 (64%) were TB lymphadenitis), while 25 (33.4%) had malignant LNs. Malignant LNs presented sonographically as a mass lesion (p=0.021) and had higher Doppler density and maximum velocity (p=0.002 and 0.016, respectively). SWE speed and velocity were significantly higher in the malignant LNs (p=0.027 and 0.032, respectively), compared to inflammatory LNs, but didn’t differ from TB lymphadenitis. A cut-off value of 30.7 Kpa achieved 56% sensitivity and 76% specificity, (AUC=0.65) for the prediction of malignancy. SWE correlated weakly with LN size (r=0.3, p=0.029). Conclusion: SWE along with grey scale and color Doppler US, is a simple, safe, non- invasive, and effective tool for assessing intra-abdominal lymph nodes.
520		3	_aﯾﻌﺪ ﺗﻀﺨﻢ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ ھﻮ ﺣﺎﻟﺔ ﺷﺎﺋﻌﺔ ﻓﻲ اﻟﻤﻤﺎرﺳﺔ اﻟﻄﺒﯿﺔ اﻟﯿﻮﻣﯿﺔ وذات أھﻤﯿﺔ ﺗﺸﺨﯿﺼﯿﺔ ﻛﺒﯿﺮة، ﺣﯿﺚ ﯾﻤﻜﻦ أن ﯾﻜﻮن ﻋﻼﻣﺔ ﻋﻠﻰ ﺣﺎﻻت ﻣﺮﺿﯿﺔ ﻛﺎﻣﻨﺔ ﻣﺨﺘﻠﻔﺔ. ﺗﻌﺘﺒﺮ ﺗﻘﻨﯿﺔ ﺗﺼﻮﯾﺮ اﻟﻤﺮوﻧﺔ ﺑﻤﻮﺟﺔ اﻟﻘﺺ ﺗﻘﻨﯿﺔ ﺣﺪﯾﺜﺔ ﺗُﻈﮭﺮ ﺻﻼﺑﺔ اﻷﻧﺴﺠﺔ ﻣﻦ ﺧﻼل ﺗﺼﻮﯾﺮ ﻣﻠﻮن أو ﻗﯿﺎﺳﺎت ﺳﺮﻋﺔ اﻟﻤﻮﺟﺎت اﻟﻘﺼﯿﺮة ﻋﺒﺮ اﻟﻜﺸﻒ ﻋﻦ اﻟﺘﻐﯿﺮات ﻓﻲ إزاﺣﺔ اﻷﻧﺴﺠﺔ أو ﺳﺮﻋﺘﮭﺎ. وﻋﻨﺪ دﻣﺠﮭﺎ ﻣﻊ اﻟﺘﺼﻮﯾﺮ ﺑﺎﻟﻤﻮﺟﺎت ﻓﻮق اﻟﺼﻮﺗﯿﺔ ﺛﻨﺎﺋﯿﺔ اﻷﺑﻌﺎد، ﻓﺈﻧﮭﺎ ﺗُﺤﺴﻦ ﻣﻦ اﻟﺪﻗﺔ اﻟﺘﺸﺨﯿﺼﯿﺔ ﺑﺸﻜﻞ ﻛﺒﯿﺮ، ﻣﻤﺎ ﯾُﻌﺰز اﻟﻘﺪرة ﻋﻠﻰ اﻟﺘﻤﯿﯿﺰ ﺑﯿﻦ اﻟﻌﻘﺪ اﻟﻠﻤﻔﺎوﯾﺔ اﻟﺤﻤﯿﺪة واﻟﺨﺒﯿﺜﺔ. ھﺪﻓﺖ ھﺬه اﻟﺪراﺳﺔ إﻟﻰ ﺗﻘﯿﯿﻢ دور اﻟﺘﺼﻮﯾﺮ ﺑﺎﻟﻤﻮﺟﺎت ﻓﻮق اﻟﺼﻮﺗﯿﺔ، وﻓﺤﺺ دوﺑﻠﺮ/اﻟﺪوﺑﻠﻜﺲ وﺗﻘﻨﯿﺔ اﻟﺘﺼﻮﯾﺮ اﻟﻤﺮن ﺑﻤﻮﺟﺔ اﻟﻘﺺ ﻓﻲ ﺗﻮﺻﯿﻒ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ ﺑﺎﻟﺒﻄﻦ ذات اﻷﺳﺒﺎب اﻟﻤﺨﺘﻠﻔﺔ. ﺗﺸﻤﻞ اﻟﺪراﺳﺔ 75 ﻣﺮﯾﻀﺎً وﺗﻢ ﺗﺠﻤﯿﻊ اﻟﻤﺮﺿﻲ اﻟﻤﺘﺮددﯾﻦ ﻋﻠﻰ ﻣﺮﻛﺰ اﻟﻔﺤﺺ ﺑﺎﻟﻤﻮﺟﺎت ﻓﻮق اﻟﺼﻮﺗﯿﺔ ﺑﻘﺴﻢ اﻷﻣﺮاض اﻟﻤﺘﻮطﻨﺔ ﺑﺎﻟﻘﺼﺮ اﻟﻌﯿﻨﻲ وﺗﻢ ﺗﺼﻨﯿﻔﮭﻢ ﻻﺣﻘﺎً إﻟﻰ ﻣﺠﻤﻮﻋﺘﯿﻦ: ﻏﺪد ﻟﯿﻤﻔﺎوﯾﺔ ﺧﺒﯿﺜﺔ واﻟﺘﮭﺎﺑﯿﺔ، ﺑﻨﺎًء ﻋﻠﻰ ﻧﺘﺎﺋﺞ ﻓﺤﺺ اﻟﻌﯿﻨﺔ اﻟﻤﺄﺧﻮذة ﻣﻦ ﻧﺴﯿﺞ اﻟﻐﺪد اﻟﻠﯿﻤﻔﺎوﯾﺔ. ﺑﻌﺪ اﻟﺤﺼﻮل ﻋﻠﻰ ﻣﻮاﻓﻘﺔ ﻣﺴﺘﻨﯿﺮة، وأﺧﺬ اﻟﺘﺎرﯾﺦ اﻟﻤﺮﺿﻲ اﻟﻜﺎﻣﻞ، وإﺟﺮاء اﻟﻔﺤﺺ اﻟﺴﺮﯾﺮي، وﺟﻤﻊ ﻧﺘﺎﺋﺞ اﻟﺘﺤﺎﻟﯿﻞ اﻟﻤﻌﻤﻠﯿﺔ، ﺧﻀﻊ ﺟﻤﯿﻊ اﻟﻤﺮﺿﻰ ﻟﻔﺤﺺ ﺷﺎﻣﻞ ﺑﺎﻟﻤﻮﺟﺎت ﻓﻮق اﻟﺼﻮﺗﯿﺔ ﻋﺒﺮ اﻟﺒﻄﻦ. ﺗﻢ إﺟﺮاء ﻓﺤﺺ دﻗﯿﻖ ﻟﻠﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ، ﺷﻤﻞ اﻟﻤﻜﺎن، اﻟﺤﺠﻢ، اﻟﻌﺪد، اﻟﺸﻜﻞ. ﺗﻼ ذﻟﻚ إﺟﺮاء ﻓﺤﺺ دوﺑﻠﺮ/دوﺑﻠﻜﺲ ﻟﺘﻘﯿﯿﻢ وﺟﻮد أوﻋﯿﺔ دﻣﻮﯾﺔ ﻓﻲ اﻟﻐﺪد اﻟﻠﯿﻤﻔﺎوﯾﺔ، وﻛﺜﺎﻓﺘﮭﺎ، وﺗﻮزﯾﻌﮭﺎ. ﺗﻢ ﺗﻘﯿﯿﻢ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ اﻟﻤﺘﻀﺨﻤﺔ ﺑﺎﺳﺘﺨﺪام اﻟﺘﺼﻮﯾﺮ اﻟﻤﺮن ﺑﻤﻮﺟﺔ اﻟﻘﺺ ﺣﯿﺚ ﺗﻢ ﻗﯿﺎس ﺻﻼﺑﺔ اﻷﻧﺴﺠﺔ واﺳﺘﺨﺪام ﻣﺘﻮﺳﻂ ﺛﻼث ﻗﯿﺎﺳﺎت ﻣﺘﺘﺎﻟﯿﺔ ﻟﻠﻐﺪة اﻟﻠﻤﻔﺎوﯾﺔ ﻧﻔﺴﮭﺎ ﻓﻲ اﻟﺘﺤﻠﯿﻞ اﻹﺣﺼﺎﺋﻲ. ﺗﻢ أﺧﺬ ﻋﯿﻨﺎت اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ إﻣﺎ ﺑﺎﻟﻤﻮﺟﺎت ﻓﻮق اﻟﺼﻮﺗﯿﺔ ﻋﺒﺮ اﻟﺒﻄﻦ، أو ﺑﺎﻟﻤﻨﻈﺎر اﻟﺠﺮاﺣﻲ، أو ﻣﻨﻈﺎر اﻟﻘﺼﺒﺎت اﻟﮭﻮاﺋﯿﺔ ﺣﺴﺐ اﻟﺤﺎﻟﺔ اﻟﺴﺮﯾﺮﯾﺔ. وﻗﺪ اﻋﺘُﺒﺮ اﻟﻔﺤﺺ اﻟﻨﺴﯿﺠﻲ ھﻮ اﻟﻤﻌﯿﺎر اﻷﺳﺎﺳﻲ ﻟﺘﺸﺨﯿﺺ ﺗﻀﺨﻢ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ. أظﮭﺮت اﻟﻨﺘﺎﺋﺞ أن اﻟﻤﺮﺿﻰ اﻟﺬﯾﻦ ﻟﺪﯾﮭﻢ ﻏﺪد ﻟﻤﻔﺎوﯾﺔ ﺧﺒﯿﺜﺔ ﻛﺎﻧﻮا ﻏﺎﻟﺒﺎً ﻣﻦ اﻟﺬﻛﻮر، أﻛﺒﺮ ﺳﻨﺎً، ﻣﺪﺧﻨﯿﻦ، وﯾﻌﺎﻧﻮن ﻣﻦ ارﺗﻔﺎع ﺿﻐﻂ اﻟﺪم ﻣﻘﺎرﻧﺔً ﺑﺎﻟﻤﺠﻤﻮﻋﺔ اﻻﻟﺘﮭﺎﺑﯿﺔ. 109 ﻓﯿﻤﺎ ﯾﺘﻌﻠﻖ ﺑﺎﻟﻔﺤﺺ اﻟﻌﺎم اﻟﺸﺎﻣﻞ ﺑﺎﻟﻤﻮﺟﺎت ﻓﻮق اﻟﺼﻮﺗﯿﺔ ﻟﻠﺒﻄﻦ، ﻗﺪ ﻛﺎن ﻣﻌﻈﻢ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ اﻟﺨﺒﯿﺜﺔ ﻋﻠﻰ ﺷﻜﻞ ﻛﺘﻞ، وﺑﮭﺎ ﻧﺴﺒﺔ أﻛﺒﺮ ﻣﻦ اﻷوﻋﯿﺔ اﻟﺪﻣﻮﯾﺔ ﺑﻔﺤﺺ اﻟﺪوﺑﻠﺮ. وﻋﻨﺪ ﻣﻘﺎرﻧﺔ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ ﻓﻲ ﺣﺎﻻت اﻟﺪرن ﻣﻊ اﻟﻐﺪد اﻟﺨﺒﯿﺜﺔ، ﻛﺎﻧﺖ اﻟﻐﺪد ﻓﻲ ﺣﺎﻻت اﻟﺪرن ﺗﺘﻮاﺟﺪ أﻛﺜﺮ ﻓﻲ اﻷﻏﺸﯿﺔ ﻣﺎ ﺑﯿﻦ اﻷﻣﻌﺎء وﺑﮭﺎ أوﻋﯿﺔ دﻣﻮﯾﺔ ﻣﺘﻮاﺟﺪة أﻛﺜﺮ ﻓﻲ أطﺮاف اﻟﻐﺪة اﻟﻤﺘﻀﺨﻤﺔ ﺑﯿﻨﻤﺎ ﺗﺘﻮاﺟﺪ اﻷوﻋﯿﺔ اﻟﺪﻣﻮﯾﺔ ﺑﺎﻟﻐﺪد اﻟﺨﺒﯿﺜﺔ ﺑﻤﻨﺘﺼﻒ اﻟﻐﺪد. ﻛﺎﻧﺖ ﺻﻼﺑﺔ اﻟﻌﻘﺪ اﻟﻠﻤﻔﺎوﯾﺔ أﻋﻠﻰ ﺑﺸﻜﻞ ﻣﻠﺤﻮظ ﻓﻲ اﻟﻌﻘﺪ اﻟﺨﺒﯿﺜﺔ ﻣﻘﺎرﻧﺔ ﺑﺎﻟﻌﻘﺪ اﻻﻟﺘﮭﺎﺑﯿﺔ وﻋﻨﺪ ﻗﯿﻤﺔ ﺣﺪﯾﺔ ﺗﺒﻠﻎ 30.75kPa ، ﯾﻤﻜﻦ ﻟﺘﺼﻮﯾﺮ اﻟﻤﺮوﻧﺔ ﺑﻤﻮﺟﺔ اﻟﻘﺺ اﻟﺘﻨﺒﺆ ﺑﺨﺒﺎﺛﺔ اﻟﻌﻘﺪ اﻟﻠﻤﻔﺎوﯾﺔ. ﻛﻤﺎ ﻟﻮﺣﻆ وﺟﻮد ﻋﻼﻗﺔ ارﺗﺒﺎط ﺿﻌﯿﻔﺔ، وﻟﻜﻦ ذات دﻻﻟﺔ إﺣﺼﺎﺋﯿﺔ ﺑﯿﻦ ﻣﺘﻮﺳﻂ ﺳﺮﻋﺔ ﻣﻮﺟﺔ اﻟﻘﺺ ﻓﻲ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ وﺣﺠﻤﮭﺎ. اﺳﺘﻨﺘﺠﺖ اﻟﺪراﺳﺔ ان اﻟﺘﺼﻮﯾﺮ ﺑﺎﻟﻤﻮﺟﺎت ﻓﻮق اﻟﺼﻮﺗﯿﺔ ﻟﻠﺒﻄﻦ ﺗﻌﺘﺒﺮ وﺳﯿﻠﺔ ﺑﺴﯿﻄﺔ وآﻣﻨﺔ وﻏﯿﺮ ﺗﺪاﺧﻠﯿﺔ ﻟﻠﻜﺸﻒ ﻋﻦ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ ﺑﺎﻟﺒﻄﻦ وﺗﻮﺻﯿﻔﮭﺎ. وﺗُﻌﺪ ﺗﻘﻨﯿﺔ اﻟﺘﺼﻮﯾﺮ اﻟﻤﺮن ﺑﻤﻮﺟﺔ اﻟﻘﺺ أداة ﻣﻔﯿﺪة ﯾﻤﻜﻦ اﺳﺘﺨﺪاﻣﮭﺎ ﺑﺠﺎﻧﺐ اﻟﺘﺼﻮﯾﺮ ﺑﺎﻟﻤﻮﺟﺎت ﻓﻮق اﻟﺼﻮﺗﯿﺔ ودوﺑﻠﺮ اﻟﻤﻠﻮن ﻓﻲ ﺗﻘﯿﯿﻢ اﻟﻐﺪد اﻟﻠﻤﻔﺎوﯾﺔ ﺑﺎﻟﺒﻄﻦ ﺣﯿﺚ ﺗﺴﺎھﻢ ﻓﻲ اﺧﺘﯿﺎر اﻟﻌﻘﺪ اﻷﻛﺜﺮ اﺷﺘﺒﺎھﺎً، إﻻ أﻧﮭﺎ ﻻ ﯾﻤﻜﻦ أن ﺗﺤﻞ ﻣﺤﻞ اﻟﻔﺤﺺ اﻟﻨﺴﯿﺠﻲ ﻟﻠﻐﺪد اﻟﻤﺘﻀﺨﻤﺔ.
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650		7	_aLymphoproliferative
651		7	_aامراض الغدد الليمفاوية
653		1	_aabdominal ultrasound _aSWE _alymph nodes _amalignant _ainflammatory
700	0		_aMaha Sayed HasabAllah _ethesis advisor.
700	0		_aHany Mofeed Shehab _ethesis advisor.
700	0		_aYasmine Mohamed Gaber _ethesis advisor.
900			_b01-01-2025 _cMaha Sayed HasabAllah _cHany Mofeed Shehab _cYasmine Mohamed Gaber _UCairo University _FFaculty of Medicine _DDepartment of Endemic Medicine
905			_aShimaa _eEman Ghareb
942			_2ddc _cTH _e21 _n0
999			_c178626