000			09458namaa22004571i 4500
003			EG-GICUC
005			20260315103104.0
008			260315s2024 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a614.5924144
092			_a614.5924144 _221
097			_aPh.D
099			_aCai01.11.15.Ph.D.2025.As.E
100	0		_aAsmaa Elsayed Nasr, _epreparation.
245	1	0	_aEffect of COVID-19 vaccination on semen parameters : _ban Observational Cross-Sectional Study / _cby Asmaa Elsayed Nasr ; Supervisors Prof. Dr. Ismail Ibrahim Abo-elfotoh, Prof. Dr. Mohamed Mahmoud Kotb, Prof. Dr. Mohamed Abd-Elfatah Farag, Dr. Mostafa Abdelgalil Safwat.
246	1	5	_aﺗﺄﺛﯾر ﺗطﻌﯾم ﻛوﻓﯾد 19 ﻋﻠﻰ ﻣؤﺷرات اﻟﺳﺎﺋل اﻟﻣﻧوي : _bدراﺳﺔ ﻣﻘطﻌﯾﺔ رﺻدﯾﺔ
264		0	_c2025.
300			_a88 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (Ph.D)-Cairo University, 2025.
504			_aBibliography: pages 74-88.
520		3	_aAll humans on the planet were affected with the declaration of the COVID-19 pandemic by the WHO on March 11th 2020. The rising numbers of the newly infected coupled with the daily fatality count were followed closely by millions (Abd et al., 2022). In an effort to cope with the situation worldwide, vaccines were being developed. The testing stage for assuring efficacy and safety of the developing vaccines were conducted in three phases (Polack et al., 2020).Unfortunately the sudden acute state of the events didn’t allow for a study of the delayed effects of the vaccines being developed (Li et al., 2020). A raising concern about the effect of Corona virus infection on male fertility was brought upon by the discovery of impaired spermatogenesis in some of COVID- 19 patients. This observation was explained in two ways: - Elevation of the immune response and cytokine storm in the testis or -Autoimmune orchitis observed in pathology specimens of deceased patients of COVID -19 (Li et al., 2020). Both trans-membrane serine protease 2 and angiotensin converting enzyme 2 are targets of the virus. Unfortunately both are expressed in spermatogonia of the testis and spermatogonial stem cells, making them one of the targets of the virus. Theoretically it is possible that a resembling effect can occur in those acquiring the vaccine for it may illicit a similar immune response (Corona et al., 2022). Infertility is an important issue. It creates an array of different problems and burdens on the individual and the governments. The most pronounced of these problems are economical, social, and psychological distress to the infertile couple. Additionally there is an economical burden on the health care system (Pourmasumi et al., 2019). The concerns regarding the vaccine’s effect on male fertility is an imperative one due to:  The importance of fertility  The real possibility of testicular damage and by extension the possibility of infertility later on following COVID-19 infection  The immunological aspect of the testicular injury (Kristian et al., 2023).
520		3	_aأدى اﻻﻧﺘﺸﺎر اﻟﻮاﺳﻊ ﻟﻔﯿﺮوس اﻟﻜﻮﻓﯿﺪ 19 اﻟﻰ ﺣﺪوث ﺟﺎﺋﺤﺔ ﻋﺎﻟﻤﯿﺔ ﺗﻤﯿﺰت ﺑﺄرﺗﻔﺎع ﯾﻮﻣﻲ ﻓﻲ أﻋﺪاد اﻟﻤﺼﺎﺑﯿﻦ و أﻋﺪاد اﻟﻮﻓﯿﺎت ﻓﻲ أﻧﺤﺎء اﻟﻌﺎﻟﻢ , و ﻛﺎﻧﺖ اﻟﻐﺎﻟﺒﯿﮫ اﻟﻌﻈﻤﻰ ﻣﻦ اﻟﻤﺼﺎﺑﯿﻦ ﺗﻌﺎﻧﻲ ﻣﻦ أﻋﺮاض ﺑﺎﻟﺠﮭﺎز اﻟﺘﻨﻔﺴﻲ و ﻣﻊ ذﻟﻚ ﻟﻮﺣﻈﺖ أﻋﺮاض اﻻﺻﺎﺑﮫ ﻓﻲ أﺟﮭﺰة أﺧﺮى ﺑﺎﻟﺠﺴﻢ ﻣﻦ ﺿﻤﻨﮭﻢ اﻟﺠﮭﺎز اﻟﺘﻨﺎﺳﻠﻲ . ﺑﻌﺾ ﻣﻦ اﻟﻤﺼﺎﺑﯿﻦ ﺑﻤﺮض اﻟﻜﻮﻓﯿﺪ 19 ﻛﺎن ﻟﻮﺣﻆ ﻋﻠﯿﮭﻢ ﺗﺄﺛﺮ ﻋﻤﻠﯿﺔ أﻧﺘﺎج اﻟﺤﯿﻮاﻧﺎت اﻟﻤﻨﻮﯾﮫ و اﻟﺬي ﯾﻤﻜﻦ ﺗﻔﺴﯿﺮه ﺑﺘﻨﺸﯿﻂ اﻷﺳﺘﺠﺎﺑﮫ اﻟﻤﻨﺎﻋﯿﮫ ﺑﺎﻟﺨﺼﯿﺘﯿﻦ و اﻟﻌﺎﺻﻔﮫ اﻟﺴﯿﺘﻮﻛﯿﻨﯿﮫ , ﻛﻤﺎ ﻟﻮﺣﻆ أﯾﻀﺎ و ﺟﻮد دﻟﯿﻞ ﻋﻠﻰ اﻟﺘﮭﺎب اﻟﺨﺼﯿﺔ اﻟﻤﻨﺎﻋﻲ اﻟﺬاﺗﻲ ﻓﻲ ﻋﯿﻨﺎت ﻣﻦ ﺧﺼﯿﺔ ﺑﻌﺾ اﻟﻤﺘﻮﻓﯿﻦ ﻣﻦ اﻟﻤﺮض , و ﻣﻦ ﺛﻢ ﻗﺪ ﺗﺤﺪث أﺳﺘﺠﺎﺑﺔ ﻣﻤﺎﺛﻠﮫ أﺛﺮ ﺗﻠﻘﻲ اﻟﻠﻘﺎح. أدت اﻟﺰﯾﺎده اﻟﯿﻮﻣﯿﮫ ﻓﻲ أﻋﺪاد اﻟﻮﻓﺎﯾﺎت و اﻟﻤﺼﺎﺑﯿﻦ اﻟﻰ ﺣﺎﺟﮫ ﻣﻠﺤﺔ ﻟﺘﻄﻮﯾﺮ ﻟﻘﺎﺣﺎت ﻋﺪﯾﺪه و ﺳﺮﯾﻌﮫ ﻣﻤﺎ أدى اﻟﻰ ﺗﻄﻮﯾﺮ و ﺗﻮﻓﯿﺮ اﻟﻠﻘﺎﺣﺎت ﺑﺪون دراﺳﺔ اﻟﺘﺄﺛﯿﺮات اﻟﻤﺤﺘﻤﻠﮫ اﻟﻤﺘﺄﺧﺮة و ﺑﻌﯿﺪة اﻟﻤﺪى. وﻣﻊ ظﮭﻮر اﻟﺨﻮف ﻣﻦ اﻟﻠﻘﺎﺣﺎت اﻟﺠﺪﯾﺪه و ﺷﯿﻮع ﻧﻈﺮﯾﺎت اﻟﻤﺆاﻣﺮة ﺑﺨﺼﻮص اﻟﻠﻘﺎﺣﺎت ﺗﺤﺘﻢ ﺿﺮورة دراﺳﺔ ﻣﺪى ﺳﻼﻣﺔ اﻟﻠﻘﺎح ﻣﻦ اﺟﻞ اﻟﻤﺤﺎﻓﻈﮫ ﻋﻠﻰ ﺳﻼﻣﺔ اﻻﺷﺨﺎص. ﺗﮭﺪف ھﺬه اﻟﺪراﺳﺔ اﻟﻰ ﺗﻘﯿﻢ اﻟﺘﺄﺛﯿﺮاﻟﻤﺘﺄﺧﺮ اﻟﻤﺤﺘﻤﻞ ﻟﻠﻘﺎح ﺳﯿﻨﻮﻓﺎرم – ﻟﻘﺎح ﻓﯿﺮوﺳﻲ ﻣﻌﻄﻞ – ﻋﻠﻰ ﻣﻌﺎﯾﯿﺮ ﺗﺤﻠﯿﻞ اﻟﺴﺎﺋﻞ اﻟﻤﻨﻮي. ﺗﻢ ﺗﺠﻤﯿﻊ اﻟﻤﺘﻄﻮﻋﯿﻦ ﻣﻦ وﺣﺪة اﻟﺤﻘﻦ اﻟﻤﺠﮭﺮي ﺑﻤﺴﺘﺸﻔﻰ اﻟﺘﻮﻟﯿﺪ و أﻣﺮاض اﻟﻨﺴﺎء اﻟﻘﺼﺮ اﻟﻌﯿﻨﻲ. ﺗﻢ أﺷﺮاك 128 ﻣﺘﻄﻮع , ﺣﯿﺚ ﺗﻢ ﺟﻤﻊ 64 ﻋﯿﻨﺔ ﺳﺎﺋﻞ ﻣﻨﻮي ﻣﻦ رﺟﺎل أﺻﺤﺎء ﻏﯿﺮ ﻣﻠﻘﺤﯿﻦ و 64 ﻋﯿﻨﺔ ﺳﺎﺋﻞ ﻣﻨﻮي ﻣﻦ رﺟﺎل أﺻﺤﺎء ﺑﻌﺪ ﻣﺮور ﻋﺎم ﻋﻠﻰ اﻷﻗﻞ ﻣﻦ ﺗﻠﻘﻲ اﻟﺠﺮﻋﮫ اﻟﺜﺎﻧﯿﮫ ﻣﻦ اﻟﺘﻄﻌﯿﻢ. و ﻟﻘﺪ أوﺿﺤﺖ اﻟﺪراﺳﺔ ﻋﺪم وﺟﻮد ﻓﻮارق ذات دﻻﻻت أﺣﺼﺎﺋﯿﺔ ﺑﯿﻦ اﻟﻤﺠﻤﻮﻋﺘﯿﻦ ﻓﻲ ﻛﻞ ﻣﻦ: زﻣﻦ ﺗﺴﯿﻞ اﻟﺴﺎﺋﻞ اﻟﻤﻨﻮي , ﻛﻤﯿﺔ اﻟﺴﺎﺋﻞ اﻟﻤﻨﻮي , اﻟﺤﺮﻛﮫ اﻟﻜﻠﯿﮫ ﻟﻠﺤﯿﻮاﻧﺎت اﻟﻤﻨﻮﯾﮫ , ﻋﺪد اﻟﺤﯿﻮاﻧﺎت اﻟﻤﻨﻮﯾﮫ اﻟﻐﯿﺮ ﻣﺘﺤﺮﻛﮫ , ﻧﺴﺒﺔ ﺗﺸﻮھﺎت اﻟﺤﯿﻮاﻧﺎت اﻟﻤﻨﻮﯾﺔ , درﺟﺔ ﺣﺎﻣﻀﯿﺔ اﻟﺴﺎﺋﻞ اﻟﻤﻨﻮي , ﻟﺰوﺟﺔ اﻟﺴﺎﺋﻞ اﻟﻤﻨﻮي و وﺟﻮد ﺧﻼﯾﺎ اﺧﺮى ﻏﯿﺮ اﻟﺤﯿﻮاﻧﺎت اﻟﻤﻨﻮﯾﮫ. ﺑﯿﻨﻤﺎ ﻟﻮﺣﻆ أﺧﺘﻼﻓﺎت ذات دﻻﻟﮫ أﺣﺼﺎﺋﯿﮫ ﻓﻲ ﻛﻞ ﻣﻦ : ﺗﺮﻛﯿﺰ اﻟﺤﯿﻮاﻧﺎت اﻟﻤﻨﻮﯾﺔ ,أﺟﻤﺎﻟﻲ ﻋﺪد اﻟﺤﯿﻮاﻧﺎت اﻟﻤﻨﻮﯾﺔ , ﻧﺴﺒﺔ اﻟﺤﯿﻮاﻧﺎت اﻟﻤﻨﻮﯾﺔ ذات اﻟﺤﺮﻛﺔ اﻟﺘﻘﺪﻣﯿﺔ , ﺣﯿﺚ ﻛﺎﻧﺖ ھﺬه اﻟﺪﻻﺋﻞ ذات ﻣﺘﻮﺳﻂ أﻋﻠﻰ ﻓﻲ اﻟﻤﺠﻤﻮﻋﮫ اﻟﻐﯿﺮ ﻣﺤﺼﻨﺔ , ﺑﯿﻨﻤﺎ ﻛﺎﻧﺖ اﻟﺤﺮﻛﺔ اﻟﻐﯿﺮ ﻣﺘﻘﺪﻣﺔ ذات ﻣﺘﻮﺳﻂ أﻋﻠﻰ ﻓﻲ اﻟﻤﺠﻤﻮﻋﮫ اﻟﻤﺤﺼﻨﮫ. ﻏﯿﺮ أن ھﺬه اﻷﺧﺘﻼﻓﺎت ﺟﻤﯿﻌﮭﺎ ﻏﯿﺮ ھﺎﻣﮫ ﺳﺮﯾﺮﯾﺎ ﺣﯿﺚ أن ﺟﻤﯿﻊ اﻟﺪﻻﺋﻞ ﻓﻲ ﻛﻼ اﻟﻤﺠﻤﻮﻋﺘﺎن ﺿﻤﻦ اﻟﻘﯿﻢ اﻟﻄﺒﯿﻌﯿﮫ ﺣﺴﺐ ﻣﻘﯿﺎس ﻣﻨﻈﻤﺔ اﻟﺼﺤﺔ اﻟﻌﺎﻟﻤﯿﺔ ﻟﻌﺎم .2021 ﺗﺸﯿﺮ اﻟﺪراﺳﮫ اﻟﻰ اﻟﺴﻼﻣﮫ اﻟﻨﺴﺒﯿﮫ ﻟﻠﻘﺎح ﺳﯿﻨﻮﻓﺎرم اﻟﻤﻌﻄﻞ ﺣﯿﺚ ﻟﻢ ﯾﻜﻦ ﻟﮫ ﺗﺄﺛﯿﺮ ﺳﺮﯾﺮي ﻣﻠﺤﻮظ و ﺑﺬﻟﻚ ﯾﺘﻀﺢ ﻋﺪم وﺟﻮد أدﻟﺔ داﻣﻐﮫ ﺗﺪﻋﻢ اﻟﻤﺨﺎوف اﻟﻤﺜﺎره ﺑﺨﺼﻮص اﻟﻠﻘﺎح ﻓﻲ ھﺬه اﻟﺪراﺳﺔ
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650		0	_aCOVID-19
650		0	_aﻛوﻓﯾد 19
653		1	_aCOVID-19 _avaccination _asemen parameters
700	0		_aIsmail Ibrahim Abo-elfotoh _ethesis advisor.
700	0		_aMohamed Mahmoud Kotb _ethesis advisor.
700	0		_aMohamed Abd-Elfatah Farag _ethesis advisor.
700	0		_aMostafa Abdelgalil Safwat _ethesis advisor.
900			_b01-01-2025 _cIsmail Ibrahim Abo-elfotoh _cMohamed Mahmoud Kotb _cMohamed Abd-Elfatah Farag _cMostafa Abdelgalil Safwat _UCairo University _FFaculty of Medicine _DDepartment of Obstetrics and Gynecology
905			_aShimaa
942			_2ddc _cTH _e21 _n0
999			_c179036