000			04857namaa22004451i 4500
003			EG-GICUC
005			20260315204541.0
008			260315s2025 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a‪632.951
092			_a‪632.951 _221
097			_aM.Sc
099			_aCai01.07.04.M.Sc.2025.Aw.P
100	0		_aAwad Roshdy Abdelfatah, _epreparation.
245	1	0	_a Protecive effect of an antioxidant against oxidative stress induced by fipronil and lambada cyhalothrin insecticide in male albino rats / _cby Awad Roshdy Abdelfatah ; Supervisors Dr. Osama Mohamed Abdel-fatah, Dr. Yasmen Emam Abdel-Mobdi, Dr. Marwa Emam Hassan.
246	1	5	_aالتأثير الوقائي لمضادات الأكسدة ضد الإجهاد التأكسدي التي يسببها المبيد الحشري فبرونيل ولمبادا سيهالوثرين في ذكور الجرذان
264		0	_c2025.
300			_a96 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (M.Sc)-Cairo University, 2025.
504			_aBibliography: pages 76-96.
520		3	_aThis study was don to evaluate the biochemical constituents and antioxidant power of, pomegranate peel ethanolic extract (PPE) and to assess its hepatoprotective and renal impact in rats exposed Fipronil (FPN) and Lambda cyhalothrin (LCT) insecticides The phytochemicals were tested using LC-MS/MS, whilst the vitamins were evaluated using HPLC. For each pesticide six groups of male albino rats were ingested for three months, including the control group and those treated with PPE (400 mg/kg b.w.), FPN at low dosage (16.16 mg/kg b.w.), or high dose (48.5 mg/kg b.w.) and LCT at low dosage(2.6 mg/ kg/ b.w.) or Hight dose (7.9 mg/kg b.w.) alone or in combination with PPE. Blood and tissue samples were taken for various hematological, biochemical, and histopathological analyses. LC-MS/MS identified 21 chemicals belonging to tannins, steroids, tannins, flavonoids, phenolics, alkaloids, terpenoids, and saponins. The findings indicated that DPPH and ABTS radical assays produced the strongest antioxidant activity, exceeding that of KMnO4.Pomegranate peels contain good amounts of carbohydrate, phenols and flavonoids The biological study revealed there FPN and LCT caused dose-dependent changes in RBCs, WBCs, MCHC, PLT count, MCH, MCV, Hb, HCT, ALT, AST, ALP, Alb, TP, urea, uric acid, creatinine, Cho, Tri G, HDL, LDL, CAT, SOD, MDA, GST, testosterone levels, and histological changes in liver and kidneys. PPE administration only did not show any significant changes in all the tested parameters. Co-administration with FPN, LCT, and PPE induced a significant improvement in all the tested parameters towards the control levels, owing to their strong antioxidant activity. Consequently, PPE should be considered a dietary supplement in areas with high levels of FPN and LCT exposure.
520		3	_aأجريت هذه الدراسة لتحديد التركيب الكيميائي ونشاطه المضاد للأكسده لمستخلص قشر الرمان الإيثانولي (PPE) وتقيم تأثيره الوقائي للكبد والكلى في الجرذان لمعرضة لمبيدات الحشرات فيبرونيل (FPN) ولمباداسيهالوثرين (LCT) وتشير النتائج إلى أن تحاليل الشقوق الحرة ABTS وDPPH أظهرت أقوى نشاط مضاد للأكسدة متجاوزًا نشاط KMnO4 كما أظهرت النتائج إلى تحسن كبير في جميع المعايير المختبرة للمستويات القريبة من العادية وذلك بسبب نشاطها المضاد للأكسدة القوي، وبالتالي ينبغي اعتباره بمثابة مكمل غذائي في المناطق ذات المستويات العالية من التعرض لـ FBN وLCT.
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650		0	_ainsecticide
650		0	_aمبيد حشري
653		1	_aFipronil _ainsecticide _apomegranate peel _aoxidative damage _aantioxidant Lambda-cyhalothrin;antioxidant _aفيبرونيل _aمبيد حشري
700	0		_aOsama Mohamed Abdel-fatah _ethesis advisor.
700	0		_aYasmen Emam Abdel-Mobdi _ethesis advisor.
700	0		_aMarwa Emam Hassan _ethesis advisor.
900			_b01-01-2025 _cOsama Mohamed Abdel-fatah _cYasmen Emam Abdel-Mobdi _cMarwa Emam Hassan _UCairo University _FFaculty of Agriculture _DDepartment of Agricultural Biochemistry
905			_aShimaa
942			_2ddc _cTH _e21 _n0
999			_c179057