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| 082 | 0 | 4 | _a630.24 |
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_a630.24 _221 |
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| 097 | _aPh.D | ||
| 099 | _aCai01.07.04.Ph.D.2025.Me.B | ||
| 100 | 0 |
_aMervat Hassan Hassan Shehata, _epreparation. |
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| 245 | 1 | 0 |
_aBiological evaluation of avocado pulp and seeds extracts / _cby Mervat Hassan Hassan Shehata ; Supervisors Dr. Samir Abdel Moneim Ahmed, Dr. Ebtesam Abdel Moneim Mahmoud, Dr. Doha Abdou Mohamed. |
| 246 | 1 | 5 | _aالتقييم البيولوجى لمستخلاصات لب وبذور الأفوكادو |
| 264 | 0 | _c2025. | |
| 300 |
_a158 pages : _billustrations ; _c25 cm. + _eCD. |
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_atext _2rda content |
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_aUnmediated _2rdamedia |
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_avolume _2rdacarrier |
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| 502 | _aThesis (Ph.D)-Cairo University, 2025 | ||
| 504 | _aBibliography: pages 125-158. | ||
| 520 | 3 | _aAvocado is a fruit rich in oil and valued for its pleasant sensory qualities, high nutritional content, and health-promoting properties due to its abundance of bioactive compounds. This study aimed to evaluate the antioxidant, anti-cancer, and anti-arthritic activities of acetone extracts derived from the pulp, peel, and seed of avocado. Additionally, the study assessed the total phenolic and flavonoid content, fatty acid profiles, phytosterols, and hydrocarbon of these extracts. Antioxidant activity was measured using DPPH, ABTS, and FRAP assays. The anti- cancer effects of the extracts were tested on various cancer cell lines, including liver, colorectal, and breast cancer. The anti-arthritic potential of the avocado pulp extract was evaluated using the adjuvant-induced arthritis (AIA) model in rats. Gas chromatography-mass spectrometry (GC-MS) was used to characterize the extracts. The analysis revealed that the acetone extracts of pulp, peel, and seed contained total phenolic contents of 58.6, 92.9, and 91.8 mg GAE/g extract, respectively, and total flavonoid contents of 10.8, 15.1, and 12.8 mg QE/g extract, respectively. Hydrocarbons accounted for 79.06% in pulp, 91.5% in peel, and 68.93% in seed extracts. Total phytosterol content was 8.63% in pulp, 4.17% in peel, and 9.03% in seed extracts, with stigmasterol being the predominant phytosterol in all samples. The fatty acid profile showed oleic acid as the dominant unsaturated fatty acid across all extracts. GC-MS analysis identified the presence of acetogenins, volatile compounds, phytosterols, and triterpenoids in all extracts. All samples exhibited antioxidant activity across the assays used, with varying degrees of potency. The acetone extracts of pulp, peel, and seed demonstrated anti- cancer activity against liver, breast, and colorectal cancer cell lines to different extents. Notably, the pulp extract showed meaningful anti-arthritic properties in rats, evidenced by decreased inflammation, improved antioxidant status (as shown by decreased plasma malondialdehyde levels and increased activity of antioxidant enzymes including SOD, catalase, and glutathione peroxidase), and decreased TNF-α levels. Histopathological examination of joint tissues confirmed the protective effect of the pulp extract in arthritic rats. | |
| 520 | 3 | _aكان الهدف من هذة الدراسة هو تقييم الأنشطة المضادة للأكسدة وللسرطان لمستخلصات أسيتون لب الأفوكادو والقشر والبذور كما تم تقييم التأثير المضاد لإلتهاب المفاصل الروماتويدي لمستخلص الأسيتون من لب الأفوكادو فى نموذج إلتهاب المفاصل الروماتويدي المستحث لفئران التجارب المشابة تماما للذى يحدث فى الإنسان ولتحقيق هذا الهدف تم الأستخلاص لمسحوق لب وقشر وبذور الأفوكادو المجفف بالتجفيد و تم التعرف على المركبات النشطة حيوياً بأستخدام جهاز تحليل الكروماتوجرافى الغازى وتم تقدير المحتوى الكلى للفينولات و الفلافونويد و تم تقييم النشاط المضاد للأكسدة بأستخدام ثلاثة طرق مختلفة و تم دراسة النشاط المضاد للسرطان بإستخدام أنواع مختلفه من الخلايا السرطانية (سرطان الخلايا الكبدية و سرطان الثدى الغدى و سرطان القولون والمستقيم) و تم ايضا تقييم التأثير المضاد لإلتهاب المفاصل الروماتويدي . | |
| 530 | _aIssues also as CD. | ||
| 546 | _aText in English and abstract in Arabic & English. | ||
| 650 | 0 | _aAvocado | |
| 650 | 0 | _aالأفوكادو | |
| 653 | 1 |
_aAvocado extracts _aGC analysis, _aAntioxidant _aAnti-cancer _aAnti-arthritic _aمستخلصات الأفوكادو _aالتحليل الكروماتوجرافى الغازى |
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| 700 | 0 |
_aSamir Abdel Moneim Ahmed _ethesis advisor. |
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| 700 | 0 |
_aEbtesam Abdel Moneim Mahmoud _ethesis advisor. |
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| 700 | 0 |
_aDoha Abdou Mohamed _ethesis advisor. |
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| 900 |
_b01-01-2025 _cSamir Abdel Moneim Ahmed _cEbtesam Abdel Moneim Mahmoud _cDoha Abdou Mohamed _UCairo University _FFaculty of Agriculture _DDepartment of Agricultural Biochemistry |
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| 905 | _aShimaa | ||
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_2ddc _cTH _e21 _n0 |
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| 999 | _c179059 | ||