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008			260416s2025 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng
049			_aDeposit
082	0	4	_a615.32
092			_a615.32 _221
097			_aM.Sc
099			_aCai01.08.09.M.Sc.2025.Mo.K
100	0		_aMohanad Zaki Abdelsalam Zaki, _epreparation.
245	1	0	_aKynurenine pathway as a possible pharmacological target in interferon-induced depression in rats / _cby Mohanad Zaki Abdelsalam Zaki ; Supervision Dr. Nesrine Salah Eldin El-Sayed, Dr. Gouda Kamel Helal, Dr. Reham Mohamed Essam.
246	1	5	_aالمسار الكينوريني كهدف دوائي محتمل في الاكتئاب المستحث بالإنترفيرون في الجرذان
264		0	_c2025.
300			_a134 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (M.Sc)-Cairo University, 2025.
504			_aBibliography: pages 99-133.
520		3	_a Depression is a highly prevalent and disabling disorder that is frequently linked to neuroinflammation and dysregulation of the kynurenine pathway, a major branch of tryptophan metabolism. The present study investigated the potential therapeutic effects of epigallocatechin gallate (EGCG), a polyphenolic constituent of green tea, on depressive-like behaviors and kynurenine pathway modulation in a rat model of interferon (IFN)- induced depression. Rats received IFN at a dose of 6 × 10⁴ IU/kg/day, subcutaneously (s.c.), while EGCG was administered at 20 mg/kg/day for seven consecutive days. Behavioral testing, biochemical measurements, and histopathological analyses were performed to assess the impact of EGCG on depressive-like behavior, tryptophan and serotonin metabolism, kynurenine pathway intermediates, oxidative stress parameters, neuroinflammatory cytokines, and glial activation. The results demonstrated that EGCG significantly improved depression-like behaviors, normalized serotonin levels, and decreased neurotoxic kynurenine derivatives, including quinolinic acid. In addition, EGCG attenuated oxidative stress, as indicated by lower malondialdehyde levels, reduced pro-inflammatory cytokines such as TNF-α, enhanced antioxidant defenses including glutathione, and upregulated anti- inflammatory cytokines such as IL-4. Histological evaluation further revealed that EGCG preserved hippocampal neuronal architecture and reduced glial activation, as reflected by diminished glial fibrillary acidic protein expression. Collectively, these findings suggest that EGCG exerts antidepressant-like effects by regulating the kynurenine pathway, mitigating neuroinflammation, and protecting neuronal integrity, underscoring its potential as a therapeutic agent in depression management.
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650		0	_aPharmacology and Toxicology
653		1	_aDepression
700	0		_aNesrine Salah Eldin El-Sayed _ethesis advisor.
900			_b01-01-2025 _cNesrine Salah Eldin El-Sayed _UCairo University _FFaculty of Pharmacy _DDepartment of Pharmacology and Toxicology
905			_aShimaa
942			_2ddc _cTH _e21 _n0
999			_c179536