000 01679cam a2200265 a 4500
003 EG-GiCUC
005 20250223030221.0
008 100420s2009 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aGift
097 _aM.Sc
099 _aCai01.34.M.Sc.2009.Ma.N
100 0 _aMai Ahmed Saad Zaghloul
245 1 0 _aNovel anticancer compounds as efficient apoptotic and potential anti - proliferative drugs in genetically modified hepatocellular carcinoma cell models /
_cMai Ahmed Saad Zaghloul ; Supervised Ahmed Ihab Abdelaziz
260 _aCairo :
_bMai Ahmed Saad Zaghloul ,
_c2009
300 _a78 Leaves :
_bcharts , facsimiles ;
_c30cm
502 _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Molecular Genetics
520 _aHepatocellular Carcinoma is one of the severe malignancies with high incidence worldwide as reported to be ranked the sixth most common cancers[2] . Several studies have investigated the underlying pathogenesis of the disease and hypothesized that the interaction between the etiological factors (e.g. HCV, HBV, AFB and cirrhosis [7] and the hepatocytic genes result in functional (imbalance between pro - apoptotic and anti - apoptotic signaling) and structural genomic alterations(loss and gain of chromosomal regions resulting in deletion of tumor suppressor genes e.g, p53 and Rb genes) constituting the basis for HCC pathogenesis [8,44,189]
700 0 _aAhmed Ihab Abdelaziz ,
_esupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aFatma
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c30054
_d30054