000 01508cam a2200265 a 4500
003 EG-GiCUC
005 20250223031030.0
008 140825s2013 ua f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aGift
097 _aM.Sc
099 _aCai01.34.M.Sc.2013.No.N
100 0 _aNoura Mohamed Salah Eldin Riad
245 1 0 _aNovel melatonergic ligands with potential MT₁⁻ selectivity :
_bSynthesis and pharmacological evaluation /
_cNoura Mohamed Salah Eldin Riad ; Supervised Darius P. Zlotos
260 _aCairo :
_bNoura Mohamed Salah Eldin Riad ,
_c2013
300 _a140 Leaves ;
_c30cm
502 _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
520 _aNumerous functions of the neurohormone melatonin are mediated through activation of the G - protein - coupled receptors MT₁⁻ and MT₂. Elucidation of the pathophysiological function of the MT₁ receptor has been hampered mainly by the limited availability of selective full agonist and full antagonist for this receptor subtype. Design and synthesis of selective MT₁ receptor ligands with higher affinity and selectivity may contribute to better understanding of physiological functions mediated by MT₁ receptors
700 0 _aDarius P. Zlotos ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c47016
_d47016