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008 141112s2014 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.07.Ph.D.2014.La.L
100 0 _aLamiaa Mohammad kamal
245 1 0 _aLeukemic stem cell enumeration in acute myeloid leukemia :
_bRelation to prognosis /
_cLamiaa Mohammad kamal ; Supervised Iman Maher Mansour , Nahed Abdelwahab Mohammad , Lobna Ossama Elmeseery
246 1 5 _aتعداد الخلايا الجذعية اللوكيميه في اللوكيميا النقيانيه الحاده وبيان العلاقه بعاقبة المرض
260 _aCairo :
_bLamiaa Mohammad kamal ,
_c2014
300 _a137 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 _a The poor response to therapy in acute myeloid leukemia (AML) raises the expectations that the presence of leukemic stem cells (LSCs) may add to therapy resistance. Using flowcytometry, we analyzed the expression of CD123 among CD34+CD38- cells in AML patients at initial diagnosis and on day 14 post induction. We concluded thatCD123 may be used as marker of LSCs in AML, presence of LSCs at diagnosis had no prognostic impact on treatment outcome and the emergence of LSCs in post induction samples may reflect an induced stem cell theory contributing further to disease resistance
530 _aIssued also as CD
653 4 _aAcute myeloid leukemia
653 4 _aInterleukin 3 receptor alpha chain
653 4 _aLeukemic stem cell
700 0 _aIman Maher Mansour ,
_eSupervisor
700 0 _aLobna Ossama Elmeseery ,
_eSupervisor
700 0 _aNahed Abdelwahab Mohammad ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c48196
_d48196