000			02276cam a2200349 a 4500
003			EG-GiCUC
005			20250223031138.0
008			150210s2014 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.07.Ph.D.2014.He.P
100	0		_aHebat Allah Ahmed Mahmoud Ahmed
245	1	4	_aThe prognostic value of adenosine triphosphate (ATP) binding Cassette (ABCB5) and Multidrug resistance (MDR1) genes` expression in acute leukemias / _cHebat Allah Ahmed Mahmoud Ahmed ; Supervised Hala M. Farawela , Hamdy M. Zawam , Mervat M. Khorshied
246	1	5	_aالقيمه التعبيريه و النذيره لجينات ادينوسين ثلاثى الفوسفات كاسيت الملزم (ايه بى س بى 5) و لتحديد المقاومه المتعدده للادويه1(ام دى ار 1) فى سرطان الدم الحاد
260			_aCairo : _bHebat Allah Ahmed Mahmoud Ahmed , _c2014
300			_a264 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aMultidrug resistance represents a major obstacle in the chemotherapeutic treatment of acute leukemia (AL). Adenosine triphosphate ATP - binding cassette (ABCB5) and multidrug resistance (MDR1) genes are integral membrane proteins belonging to ATP - binding cassette transporters superfamily. The present work aimed to investigate the impact of ABCB5 and MDR1 genes expression on the response to chemotherapy in a cohort of Egyptian acute leukemia patients. The study included 90 patients; 53 AML cases and 37 ALL cases in addition to 20 healthy volunteers as controls. Quantitative assessment of MDR1 and ABCB5 genes expression was performed by quantitative real-time polymerase chain reaction qPCR
530			_aIssued also as CD
653		4	_aABCB5
653		4	_aGene expression
653		4	_aMDR1
700	0		_aHala Mohamed Farawela , _eSupervisor
700	0		_aHamdy Mohamed Zawam , _eSupervisor
700	0		_aMervat Mohamed Khorshied , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c49302 _d49302