000			02267cam a2200349 a 4500
003			EG-GiCUC
005			20250223031139.0
008			150212s2014 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.10.07.Ph.D.2014.Ma.I
100	0		_aMaged Fathy Abdelzaher Ali
245	1	0	_aIn vitro and in vivo studies on aluminum hepatotoxicity in rats / _cMaged Fathy Abdelzaher Ali ; Supervised Abdelazeim Ali Ahmed Khalaf , Osama Samir Eltawil , Ashraf Mohamed Hassan Morgan
246	1	5	_aدراسات على السمية الكبدية للألومنيوم معمليا وعلى الفئران
260			_aCairo : _bMaged Fathy Abdelzaher Ali , _c2014
300			_a191 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Forensic Medicine and Toxicology
520			_aAluminum is a silver-white, malleable, and ductile metal and the third most abundant element in the earth{u2019}s crust, comprising 8.3 percent of its volume. This study concerns with Al hepatoxicity either in vitro or in vivo and the role of DFO and L1as chelating agents to alleviate this effect. Isolated rat hepatocytes were exposed to different concentrations of AlCl (5, 10, 20 æM) to examine AlCl-induced hepatotoxicity. The isolated hepatocytes at the submaximal dose of ALCl were pre-treated with either DFO or L1 to determine their protective effects. Present results indicated that the viability and enzymatic leakage % of LDH, ALT, and AST were significantly affected by AlCl toxicity. Oxidative stress assessed by GSH & TBA-RS levels was also observed. Addition of DFO & L1 to incubated hepatocytes 60 minutes before AlCl exposure resulted in marked ameliorating effect
530			_aIssued also as CD
653		4	_aAluminum
653		4	_aHepatotoxicity
653		4	_aIsolated rat hepatocytes
700	0		_aAbdelazeim Ali Ahmed Khalaf , _eSupervisor
700	0		_aAshraf Mohamed Hassan Morgan , _eSupervisor
700	0		_aOsama Samir Eltawil , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAml _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c49338 _d49338