| 000 | 02553cam a2200337 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031149.0 | ||
| 008 | 150302s2014 ua do f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.09.M.Sc.2014.Di.S | ||
| 100 | 0 | _aDiaa Eldeen Ragab Mahmoud Sakr | |
| 245 | 1 | 0 |
_aStudy on the effect of cilostazol on experimentally induced renal failure in rats / _cDiaa Eldeen Ragab Mahmoud Sakr ; Supervised Hanan Elabhar , Dalaal Abdallah |
| 246 | 1 | 5 | _aدارسة تجريبية حول تأثير السيلوستازول على الفشل الكلوى المحدث تجريبيا فى الجرذان |
| 260 |
_aCairo : _bDiaa Eldeen Ragab Mahmoud Sakr , _c2014 |
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| 300 |
_a162 P. : _bcharts , photographs ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aCilostazol, a phosphodiesterase- III inhibitor, reportedly exhibits positive effects against Ischemia / reperfusion (I / R) induced injury in several models. However, its potential role against the renal I / R insult has not been elucidated. To test whether the PPAR- Þ (of peroxisome proliferator activated receptor gamma) pathway is involved in the cilostazol effect, rats were randomized into sham, I / R, cilostazol (50 and 100 mg / kg per day, orally), pioglitazone (3 and 10 mg / kg per day, orally) and their combination at the low dose levels. Drugs regimens were administered for 14 days prior to the I/R induction. Pretreatment with cilostazol or pioglitazone provided significant protection against the I/R-induced renal injury as manifested by the attenuated serum levels of creatinine, blood urea nitrogen and cystatin C. Both drugs have also opposed the I/R-induced elevation in tissue contents/activity of neutrophil gelatinase - associated lipocalin (NGAL), kidney injury molecule -1 (Kim -1), nuclear factor- кB, interleukin -18, caspase -1, as well as malondialdehyde, iNOS, myeloperoxidase, ICAM 1 and VCAM 1. Nevertheless, the drugs increased both the PPAR- Þ activity and the content of glutathione | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCilostazol | |
| 653 | 4 | _aIschemia reperfusion | |
| 653 | 4 | _aPoiglitazone | |
| 700 | 0 |
_aDalaal Moustafa Abdallah , _eSupervisor |
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| 700 | 0 |
_aHanan Sala Eldeen Elabhar , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c49645 _d49645 |
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