000			03000cam a2200349 a 4500
003			EG-GiCUC
005			20250223031227.0
008			150514s2014 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.21.M.Sc.2014.Ah.B
100	0		_aAhmed AbuAlhasan Badawy
245	1	0	_aBrain diffusion tensor imaging study in fatigue associated with multiple sclerosis / _cAhmed Abu Alhasan Badawy ; Supervised Foraysa Alsayed Mohamed Talaat , Ayman Abd Alhamid Albasmy , Eman Hasan Ahmed
246	1	5	_aدراسة الرنين المغناطيسي للمخ باستخدام الانتشار الموتر في الإجهاد المصاحب لمرض التصلب المتناثر
260			_aCairo : _bAhmed AbuAlhasan Badawy , _c2014
300			_a118 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry
520			_aObjectives: To identify the relationship between fatigue associated with multiple sclerosis (MS) and frontal white matter (WM) integrity through the study of the relationship between fatigue and frontal WM fractional anisotropy (FA) measured with Diffusion Tensor Imaging (DTI). Methods: The study was conducted on 33 patients with relapsing remitting MS and 13 healthy controls. All patients were subjected to the detailed neurological evaluation, Expanded Disability Status Scale (EDSS) and Fatigue Severity Scale (FSS). Patients were grouped according to FSS into fatigued (FSS {u2265} 4; n=15) and non-fatigued (FSS > 4; n=18) subgroups. Beck's Depression Inventory was used to exclude patients with clinically relevant depression. Using DTI, FA was measured to determine frontal WM integrity. Results: Fatigued MS patients presented with older age (p {u02C2}0.001), longer disease duration (p = 0.02) and lower FA values (p {u2264} 0.002) than non-fatigued patients. No differences in fatigue related to gender among MS patients. FSS scores were correlated with measured FA values in right (p {u02C2}0.001, r = {u2013} 0.627) and left (p {u02C2}0.001, r = {u2013} 0.758) frontal WM, age (p < 0.025, r =0.391) and disease duration (p = 0.015, r = 0.418) but not with EDSS. Compared with controls, all MS patients showed lower FA values (p {u02C2}0.001).Conclusion: MS related fatigue is likely to be the result of regional disruption of frontal white matter networks. It is more severe with older age and longer disease duration. It is independent of disability and gender
530			_aIssued also as CD
653		4	_aDiffusion Tensor Imaging
653		4	_aFatigue
653		4	_aMultiple Sclerosis
700	0		_aAyman AbdAlhamid Albasmy , _eSupervisor
700	0		_aEman Hasan Ahmed , _eSupervisor
700	0		_aForaysa Alsayed Mohamed Talaat , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_eRevisorNazla
942			_2ddc _cTH
999			_c50906 _d50906