000			02258cam a2200337 a 4500
003			EG-GiCUC
005			20250223031229.0
008			150520s2014 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.06.M.Sc.2014.No.R
100	0		_aNoha Ramadan Elsayed Barhim
245	1	4	_aThe role of insulin resistance (HOMA-IR) in the development of hepatocellular carcinoma associated with chronic hepatitis C genotype- 4 infection / _cNoha Ramadan Elsayed Barhim ; Supervised Abdelgawad M. Hashem , Amal Ahmed Mohamed
246	1	5	_a HCV- gentotype فى تطور سرطان الكبد المرتبط - بالالتهاب الكبدى المزمن سى النوع الرابع4 HOMA-IRدور مقاومة الانسولين
260			_aCairo : _bNoha Ramadan Elsayed Barhim , _c2014
300			_a111 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology
520			_aHCV is a major cause of chronic hepatitis and HCC. Different HCV genotypes show characteristic variations in their pathological properties. IR occurs early in HCV infection and may synergize with viral hepatitis in HCC development. Egypt has the highest reported rates of HCV infection (predominantly genotype 4) in the world; this study investigated effects of HCV- 4 on prevalence of insulin resistance in CHC and HCC in Egyptian patients. 50 CHC patients, 50 HCC patients and 20 normal subjects were studied. IR was estimated using HOMA-IR index and HCV-4 load was determined using real-time polymerase chain reaction. Hepatitis B virus was excluded by ELISA. Standard laboratory and histopathological investigations were undertaken to characterize liver function and for grading and staging of CHC; HCC staging was undertaken using intraoperative samples
530			_aIssued also as CD
653		4	_aHCC
653		4	_aHCV
653		4	_aHCV-4
700	0		_aAbdelgawad M. Hashem , _eSupervisor
700	0		_aAmal Ahmed Mohamed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c50974 _d50974