| 000 | 02599cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031247.0 | ||
| 008 | 150708s2014 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.03.Ph.D.2014.Da.D | ||
| 100 | 0 | _aDalia Ahmed Ali Elhaddad | |
| 245 | 1 | 0 |
_aDevelopment of analytical methods for the determination of some gastrointestinal tract drugs / _cDalia Ahmed Ali Elhaddad ; Supervised Badr Edeen A. Elzeany , Samah S. Abbas , Zeinab A. Elsherif |
| 246 | 1 | 5 | _aاستنباط طرق تحليل لتعيين بعض ادوية الجهاز الهضمى |
| 260 |
_aCairo : _bDalia Ahmed Ali Elhaddad , _c2014 |
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| 300 |
_a231 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry | ||
| 520 | _aDifferent methods for the determination of some gastrointestinal drugs including Roxatidine acetate, Tiemonium methylsulphate and Pinaverium bromide were studied. For Roxatidine acetate, stability-indicating TLC-Densitometric, HPLC, ion selective electrode and spectrophotometric D1 methods in the presence of its hydrolytic degradation products have been developed besides establish the degradation pathway by LC-MS. For Tiemonium methylsulphate, stability-indicating TLC-densitometric, HPLC, and spectrophotometric isoabsorptive point, ratio subtraction, D1 and DD1 methods in the presence of its degradation products have been developed besides establish the degradation pathway by LC-MS. For Pinaverium bromide, stability-indicating TLC-densitometric, HPLC and ion selective electrode in the presence of its acid degradation product have been developed besides establish the degradation pathway by LC-MS. All the proposed methods were used for the determination of the cited drugs in bulk powder, pharmaceutical formulations, in presence of their degradation products. The validation was assessed according to ICH guidelines. The obtained results were statistically compared to the manufacturer{u2019}s ones with no significant difference between them | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aPinaverium bromide | |
| 653 | 4 | _aRoxatidine acetate | |
| 653 | 4 | _aTiemonium methylsulphate | |
| 700 | 0 |
_aBadr Eldeen Abdelhalim Elzeany , _eSupervisor |
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| 700 | 0 |
_aSamah Sayed Abbas , _eSupervisor |
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| 700 | 0 |
_aZeinab Abdelaziz Elsherif , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aEnas _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c51605 _d51605 |
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