000 02586cam a2200349 a 4500
003 EG-GiCUC
005 20250223031256.0
008 150810s2014 ua h f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.10.10.M.Sc.2014.Su.D
100 0 _aSusan Abdelnafea Ismail Mohamed
245 1 0 _aDifferentiation between mycobacterium bovis and mycobacterium tuberculosis in cattle milk and lymphnodes using multiplex /
_cSusan Abdelnafea Ismail Mohamed ; Supervised Khaled Farouk Elamry , Salah Eldin Abdelkarim Selim , Mohamed Galal Aggour
246 1 5 _aالتمييز بين مايكوباكتيريم بوفيس و مايكوباكتيريم تيوبركيلوزيس فى الالبان و الغدد الليمفاوية للماشية باستخدام تفاعل البلمرة التسلسى اللحظى المتعدد
260 _aCairo :
_bSusan Abdelnafea Ismail Mohamed ,
_c2014
300 _a109 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Microbiology
520 _aMycobacterium bovis, a member of the M. tuberculosis complex (MTC), is the causative agent of bovine tuberculosis. Detection of M. bovis and M. tuberculosis using conventional culture - and biochemical - based assays is time - consuming. Therefore, a simple and sensitive molecular assay for rapid detection would be of great help in specific situations such as faster diagnosis of bovine tuberculosis (bTB) infection in the abattoirs. A novel multiplex real-time PCR assay was developed and applied directly to biological samples with evidence of bTB and it was allowed to differentiate between M. bovis and M. tuberculosis. The primers and TaqMan probes were designed to target the IS1081gene, the multi-copy insertion element in the MTC and the 12.7 - kb fragment which presents in M. tuberculosis, not in the M. bovis genome. The assay was optimized and validated by testing 10 species of mycobacteria including M. bovis and M. tuberculosis, and 4 other bacterial species such as escherichia coli
530 _aIssued also as CD
653 4 _aM. tuberculosis complex
653 4 _aMycobacterium bovis
653 4 _aReal time PCR
700 0 _aKhaled Farouk Elamry ,
_eSupervisor
700 0 _aMohamed Galal Aggour ,
_eSupervisor
700 0 _aSalah Eldin Abdelkarim Selim ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c51906
_d51906