| 000 | 02726cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031351.0 | ||
| 008 | 151209s2015 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.27.Ph.D.2015.Mo.E | ||
| 100 | 0 | _aMohammed Hussien Mostafa Elmahdy | |
| 245 | 1 | 0 |
_aEvaluation of the role of keratinocytes apoptosis and impaired cell to cell adhesion in vitiligo: Immunohistochemical expression of MART1, P53 and E-cadherin / _cMohammed Hussien Mostafa Elmahdy ; Supervised Naiema A.M. Marie , Samia Mohammed Gabal , Mostafa Samy Salem |
| 246 | 1 | 5 | _a(E-cadherin) و (P53)(MART) تقييم دور موت الخلايا الكيراتينية المبرمج و اضطراب اتصال الخلايا ببعضها في البهاق: التعبير المناعي لكل من |
| 260 |
_aCairo : _bMohammed Hussien Mostafa Elmahdy , _c2015 |
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| 300 |
_a125 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology | ||
| 520 | _aBackground: Vitiligo is an acquired, hypomelanotic skin disorder characterized by circumscribed depigmented macules. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes. Some studies supported the hypothesis that keratinocytes apoptosis and impaired intercellular adhesion may play a role in the pathogenesis of vitiligo. Objectives: To assess the role of keratinocytes apoptosis and impaired intercellular adhesion in the pathogenesis of vitiligo through the studying of immunohistochemical presence and distribution of MART1, P53 and E-cadherin in the epidermis Results: Regarding to immunostaining of both E-cadherin & P53, there was a highly significant difference between lesional biopsies of cases and control groups. Also there was a highly significant difference between lesional biopsies of cases and perilesional and non lesional biopsies of the same cases. No significant difference was noted regarding the disease stability. Conclusion: vitiligo is not a disease confined to melanocytes. Keratinocytes apoptosis and impaired cell to cell adhesion may play prominent role in the pathogenesis of the disease. | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aApoptosis | |
| 653 | 4 | _aCell adhesion | |
| 653 | 4 | _aVitiligo | |
| 700 | 0 |
_aMostafa Samy Salem , _eSupervisor |
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| 700 | 0 |
_aNaiema Abdelmonaem Marie , _eSupervisor |
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| 700 | 0 |
_aSamia Mohammed Gabal , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c53842 _d53842 |
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