000			02667cam a2200349 a 4500
003			EG-GiCUC
005			20250223031405.0
008			160106s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.27.M.Sc.2015.St.I
100	0		_aStephen Lokudu Loku Lomin
245	1	0	_aImmunohistochemical study of Survivin in some subtypes of breast carcinoma / _cStephen Lokudu Loku Lomin ; Supervised Maha Mosaad Mosaad , Mostafa Mohamed Sami Salem , Lubna Omar Elfarouk Abdelsalam
246	1	5	_aدراسة كيميائية نسيجية مناعية لسفافين فى بعض انواع سرطان الثدى
260			_aCairo : _bStephen Lokudu Loku Lomin , _c2015
300			_a112 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology
520			_aSurvivin is a cancer gene that is overexpressed in differentiated tissues at high levels in vast majority of tumours. It is novel member of the inhibitor of apoptosis gene family that has been shown to inhibit apoptosis and promote mitosis. Many studies showed aberrant expression of survivin. Clinicopathologic investigations on the role of surviving in breast cancer focusing on its importance as prognostic factors have been limited. In this review, we assessed the expression of survivin in some subtypes of breast cancer. Our retrospective study comprised of 40 specimens of breast cancer. Sample from archived blocks were immunostained for survivin. Survivin expression was evaluated and a weighted score with regards to the intensity and percentage expression of tumour cells were assessed. Survivin expression was detected in 90% of breast carcinomas. The adjacent normal breast tissue was negative for the immunostain. Survivin expression showed significant association with tumour histologic stage, and Her2 status. There was no significant association with age of patients, tumour size, tumour grade, nodal status, estrogen receptor status, and progesterone receptor status. In conclusion, overexpression of Survivin is associated with parameters of poor prognosis in some subtypes of breast carcinoma
530			_aIssued also as CD
653		4	_aImmunohistochemical
653		4	_aParameters
653		4	_aSurvivin
700	0		_aLubna Omar Elfarouk Abdelsalam , _eSupervisor
700	0		_aMaha Mosaad Mosaad , _eSupervisor
700	0		_aMostafa Mohamed Sami Salem , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c54319 _d54319