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008 160112s2015 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.08.06.M.Sc.2015.Ha.P
100 0 _aHanzada Tawfik Mohamed Noor Eldin
245 1 0 _aPatterns of colonization and infection among methicillin resistant staphylococcus aureus local isolates from intensive care units /
_cHanzada Tawfik Mohamed Noor Eldin ; Supervised Abdelgawad Hashem , Yasser Elmohammady Ragab , Aymen Samir Yassin
246 1 5 _a المقاومة للميثيسيلين بين عزلات محلية من وحدات العناية المركزةStaphylococcus aureus أنماط الاستعمار والعدوى بالبكتيريا
260 _aCairo :
_bHanzada Tawfik Mohamed Noor Eldin ,
_c2015
300 _a110 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology
520 _aMethicillin-resistant Staphylococcus aureus (MRSA) is characterized by its resistance to almost all beta lactams and other antibiotics belonging to various classes. The ability of MRSA to spread in hospitals, particularly in intensive care units (ICUs) has posed a major challenge for infection control worldwide. Based on their localization in the human body, hospital-acquired MRSA (HA-MRSA) can be classified into colonized or infectious. The aim of this work is to conduct an analysis to differentiate between these two classes. From a total of 100 isolates collected from the ICU of two major Egyptian hospitals, 49 isolates were confirmed as MRSA, out of which, 30 isolates were infectious and 19 were colonized. Biofilm formation showed that infectious isolates had significantly higher biofilm formation ability. The antibiogram revealed that each type of isolates had its own resistance pattern; MIC of a number of infectious isolates showed an MIC creep which can lead to future resistance. 16SrRNA sequencing confirmed the identity of several isolates; ERIC PCR typing classified the isolates into several groups. Multi locus sequence typing confirmed the relation between the isolates obtained from ERIC typing and showed the origin of some of the isolates. The resistance gene mecA was absent in one of the colonized isolates
530 _aIssued also as CD
653 4 _aColonized MRSA
653 4 _aMulti Locus Sequence Typing
653 4 _aNosocomial MRSA
700 0 _aAbdelgawad Hashem ,
_eSupervisor
700 0 _aAymen Samir Yassin ,
_eSupervisor
700 0 _aYasser Elmohammady Ragab ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSoheir
_eCataloger
942 _2ddc
_cTH
999 _c54405
_d54405