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003 EG-GiCUC
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008 160114s2015 ua hd f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.30.Ph.D.2015.Wa.N
100 0 _aWael Botros Abualyamin Ghaly
245 1 0 _aNephroprotective effect of erythropoietin in diabetic rats :
_bEvaluation of possible underlying mechanisms /
_cWael Botros Abu-Alyamin Ghaly ; Supervised Nagat Younan Mina , Samah Elattar , Mira Farouk
246 1 5 _aالتأثير الوقائي للاريثروبيوتين علي الكلي في الفئران المصابة بمرض السكر :
_bتقييم الاليات المؤدية لذلك
260 _aCairo :
_bWael Botros Abualyamin Ghaly ,
_c2015
300 _a249 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology
520 _aThe effect of erythropoietin hormone in STZ-induced diabetic nephropathy was evaluated in this study with comparing this effect with insulin treatment. 110 albino rats were randomized into 11 groups. Type I DM was induced by STZ injection at day 0 followed by serial measurements of serum glucose , insulin, serum urea , serum creatinine, urinary albumin and creatinine clearance levels in all groups. Type I DM was confirmed at week 1 by elevated serum glucose and reduced serum insulin. The diabetic nephropathy was indentified at the end of week 3 by the elevation in serum urea and creatinine levels with reduced creatinine clearance and the presence of albuminuria. Erythropoietin was given by the dose of I00 IU/kg intraperitoneally. Insulin was injected subcutaneously (S .C.) at a dose of 2U/day. Epo treated animals showed improved renal functions in the form of reduced serum urea , creatinine and urinary albumin levels as well as increased creatinine clearance values
530 _aIssued also as CD
653 4 _aErythropoietin
653 4 _aInsulin
653 4 _aType I diabetes mellitus
700 0 _aMira Farouk,
_eSupervisor
700 0 _aNagat Younan Mina ,
_eSupervisor
700 0 _aSamah Elattar ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c54460
_d54460