000			03220cam a2200349 a 4500
003			EG-GiCUC
005			20250223031410.0
008			160116s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.09.Ph.D.2015.Fa.M
100	0		_aFarouk Mostafa Faris Mohammed
245	1	0	_aManagement of intermediate coronary lesion in acute coronary syndrome / _cFarouk Mostafa Faris Mohammed ; Supervised Helmy Elghawaby , Mohamed Ashraf , Ahmed Mowafy
246	1	5	_aتقييم آفات الشرايين التاجية متوسطة الضيق حالات متلازمات القصور التاجى الحاد
260			_aCairo : _bFarouk Mostafa Faris Mohammed , _c2015
300			_a205 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine
520			_aTwenty eight patients with the diagnosis of Non ST Elevation Acute Coronary Syndromes. Coronary Angiography showed intermediate lesions assessed by QCA and IVUS. Percent area stenosis {u2265} 70%, MLA adjusted to the reference vessel diameter & MLA {u2264} 6mm2 for left main artery were the criteria for intervention. Three to six months clinical follow up regarding MACE and six months mortality.Results : Mean age was 53.2 ± 9.1 years. Males=20 (71.4%). Smoking in 17 (60.7%), hypertension in 16 (57.1%), Dyslipidemia in 12 (42.9%) & DM in 8 (28.6%). Mean BMI=23.4 ± 2.9. Twenty three patients diagnosed as UA and five patients diagnosed as NSTEMI. Mean TIMI risk score 3.1±1.4. A statistically significant higher TIMI risk score in NSTEMI group (P=0.02). Multi-vessel disease in 17 patients (60.8%). Seventy six vessels were affected with 23 Culprit vessels, 44 non-culprit vessels & 9 left main vessels. Mean syntax score 17.5 ± 8.0. sixty one intermediate lesions were detected with higher fibrofatty structure. Negative remodeling in 51% of lesions. 29 lesions in culprit vessels & 32 lesions in non-culprit vessels with higher lipidic content in lesions of culprit vessels (P<0.001) while there was a higher calcific content in lesions of non-culprit vessels (P<0.001). 27 lesions were subjected to revascularization based on IVUS measures. QCA Minimum lumen diameter was significantly lower (P=0.002) and percent diameter stenosis was significantly higher in revascularization group (P=0.02). MLA was significantly lower (P<0.001) and Percent area stenosis was significantly higher in revascularization group (P<0.001). MLA & plaque burden are the main predictors for lesion anatomical significance with (P <0.001, OR=0.25, 95% CI = 0.12-0.55) and (P=0.011 , OR=2.0 , 95% CI = 1.2-3.3) respectively related to the use of IVUS
530			_aIssued also as CD
653		4	_aACS: Acute coronary syndrome
653		4	_aIntermediate lesions
653		4	_aQCA: Quantitative coronary angiography
700	0		_aAhmed Mowafy , _eSupervisor
700	0		_aHelmy Elghawaby , _eSupervisor
700	0		_aMohamed Ashraf , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c54498 _d54498