000			02969cam a2200349 a 4500
003			EG-GiCUC
005			20250223031424.0
008			160214s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.27.M.Sc.2015.Mo.V
100	0		_aMona Mohamed Mamdouh Abdelfattah Abdelghany
245	1	0	_aValue of e-cadherin and desmin immunocytochemistry in distinguishing metastatic adenocarcinoma from reactive mesothelial cells in serous effusions / _cMona Mohamed Mamdouh Abdelfattah Abdelghany ; Supervised Gina Assaad Assaad Nakhla , Neveen Samir Tahoun , Maha Elsayed Salama
246	1	5	_aدراسة مناعية خلوية كيميائية لتعبيراي-كادهرين و ديزمين فى التفرقه بين الخلايا الظهارية التفاعلية و السرطان الغدي النقلي فى الارتشاح المصلي
260			_aCairo : _bMona Mohamed Mamdouh Abdelfattah Abdelghany , _c2015
300			_a123 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology
520			_aMaterial and methods: Fifty cases of serous effusions were examined on Papanicolaou-stained and Diff quick-stained smears as well as Paraffin-embedded cell blocks. 30 cases were diagnosed as metastatic adenocarcinoma and 20 cases were diagnosed as reactive mesothelial hyperplasia with typical cytomorphologic features. All the cases were studied for E-cadherin and desmin immunoreactivity. Results: The all cases of metastatic adenocarcinoma reacted to E-cadherin and only 3 cases reacted to desmin, whereas among the 20 cases of reactive mesothelial cell hyperplasia, 18 cases stained with desmin and only one case was stained with E-cadherin. Considering the staining of the E-cadherin and desmin under conditions that the cells were stained with E-cadherin but not with desmin, sensitivity=90%, specificity=100%, positive predictive value (PPV)=100%, negative predictive value (NPV)=87% and accuracy=94% to identify metastatic adenocarcinoma. While under conditions that the cells were stained with desmin but not with E-cadherin, sensitivity=85%, specificity=100%, positive predictive value (PPV)=100%, negative predictive value (NPV)=90% and accuracy= 94% to identify reactive mesothelial cell hyperplasia. Conclusion: Employing this short panel can be helpful for better differentiation of adenocarcinoma and reactive mesothelial cells in serous effusions
530			_aIssued also as CD
653		4	_aAdenocarcinoma
653		4	_aE-cadherin
653		4	_aReactive mesothelial cell
700	0		_aGina Assaad Assaad Nakhla , _eSupervisor
700	0		_aMaha ElSayed Salama , _eSupervisor
700	0		_aNeveen Samir Tahoun , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c54978 _d54978