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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.19.05.Ph.D.2015.Fa.O
100 0 _aFaten Awad Mohamed Awad
245 1 0 _aOutcome analysis of pediatric B-cell non hodgkin's lymphoma treated with FAB-LMB 96 /
_cFaten Awad Mohamed Awad ; Supervised Mohamed Hany Hussien , Alaa M .EL Haddad , Hany Abdelrahman Sayed
246 1 5 _aFAB-LMB 96 تحليل نتائج العلاج لمرضى سرطان الغدد الليمفاويه للاطفال المعالجين طبقا لبروتكول
260 _aCairo :
_bFaten Awad Mohamed Awad ,
_c2015
300 _a154 P. :
_bcharts . facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric oncology
520 _aBackground: Mature B cell lymphoma accounts for more than half of the NHLs occurring in children and adolescents. Outcome has improved dramatically over the past decade. Purpose: to analyze the outcome results, Overall Survival (OS) and Event Free Survival (EFS) of patients with mature B-cell Non-Hodgkin Lymphoma receiving FAB/LMB 96 protocol, the treatment related toxicity and the impact of dose density on the outcome. Results: The mean age of the patients was 6.5 years; the distribution of primary site was abdomen 68.8%, head and neck 11.4%, mediastinum 8.1 % , bone marrow involvement 4.9% & CNS involvement 4.9%. According to the histological classification, 83.6% were BL, 11.5 % DLBCL and 4.9% matures B cell (L3) leukemia. According to FAB risk group, 4.9 % were group A, 85.2% group B and 9.8 % group C. OS & EFS for the whole group was 88.1% for both with a median follow up period of 35 months. The EFS for group A was 100 %, group B 91.5% and group C 66.7%. Conclusion: the outcome of children with mature B cell NHL treated with FAB/LMB 96 protocol in NCI {u2013}Egypt was comparable to the international results. The reduction of treatment of group B patients improved the EFS and decreased the rate of toxic morbidities and mortalities
530 _aIssued also as CD
653 4 _aFAB/LMB 96
653 4 _aMature B-cell NHL
653 4 _aPediatric oncology
700 0 _aAlaa M .EL Haddad ,
_eSupervisor
700 0 _aHany Abdelrahman Sayed ,
_eSupervisor
700 0 _aMohamed Hany Hussien ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSoheir
_eCataloger
942 _2ddc
_cTH
999 _c55091
_d55091