000 02634cam a2200349 a 4500
003 EG-GiCUC
005 20250223031436.0
008 160307s2015 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.08.03.Ph.D.2015.Am.A
100 0 _aAmira Mohamed Saad Kessiba
245 1 0 _aAnalysis of selected pharmaceutical compounds containing tertiary amines /
_cAmira Mohamed Saad Kessiba ; Supervised Mohamed Abdelkawy , Ahmed Emad Elgendy , Maha Abdelmonem Hegazy
246 1 5 _aتحليل مستحضرات صيدلية منتقاه محتوية على مجموعة الامين الثلاثية
260 _aCairo :
_bAmira Mohamed Saad Kessiba ,
_c2015
300 _a331 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy- Department of Analytical Chemistry
520 _aThe thesis consists of four parts. Part I: which includes a brief introduction on amines and on the selected drugs in addition to a literature review of all the reported methods for the analysis of the selected drugs Part II: This part includes stability indicating methods for determination of Acemetacin in presence of its degradation products and impurities followed by identification of the degradation products and impurities. HPLC with UV detection, univariate and multivariate spectrophotometric methods were applied. The univariate methods include direct spectrophotometry for determination of Acemetacin and ratio subtraction method coupled with ratio difference for the determination of the degradation products and impurities. Multivariate PLS regression model was also applied. Part III: This part includes several analytical techniques for the simultaneous determination of Avanafil and Dapoxetine hydrochloride. HPLC with time programmed fluorescence was applied in addition to several spectrophotometric methods such as constant center and absorption factor spectrophotometric methods. Spectrofluorimetric methods coupled with continuous wavelets transforms and Savitzky-Golay derivitization technique were also applied for the simultaneous determination of Avanafil and Dapoxetine hydrochloride
530 _aIssued also as CD
653 4 _aAcemetacin
653 4 _aHPLC
653 4 _aStability indicating methods
700 0 _aAhmed Emad Elgendy ,
_eSupervisor
700 0 _aMaha Abdelmonem Hegazy ,
_eSupervisor
700 0 _aMohamed Abdelkawy ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c55384
_d55384