000			02953cam a2200349 a 4500
003			EG-GiCUC
005			20250223031439.0
008			160312s2015 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.09.M.Sc.2015.Is.P
100	0		_aIslam Hassan Mohamed Elsadek Abulnaga
245	1	0	_aPlasminogen activator Inhibitor 1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass / _cIslam Hassan Mohamed Elsadek Abulnaga ; Supervised Suzy Fawzy Michael , Mohamed Fawzy Abdelaleem , Mohamed Ahmed Elbadawy
246	1	5	_aمثبط منشط البلازمينوجين رقم (1) كمتنبئ لحدوث ذبذبة الأذين بعد الجراحة بعد ماكينة القلب و الرئة الصناعى
260			_aCairo : _bIslam Hassan Mohamed Elsadek Abulnaga , _c2015
300			_a219 P. ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine
520			_aPostoperative AF leads to significant morbidity and prolongation of hospital stay, and complicates 20% to 40% of surgical procedures requiring cardiopulmonarybypass (CPB).⁽¹⁾ This study aims at measuring The efficacy of plasminogen activator Inhibitor-1 (PAI - 1) as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass (CPB). We enrolled 100 adult patients undergoing elective cardiac surgery requiring CPB and who were in sinus rhythm at the time of surgery. Blood samples were obtained for measurement of plasminogen activator inhibitor - 1 (PAI - 1) in the morning of the operation and immediately after separation from CPB and administration of protamine. Patients who developed postoperative AF (28 patients, 28%) were significantly older (P=0.04), had history of hypertension (P = 0.035), performed graft to right coronary artery (P < 0.001), performed greater number of grafts (P=0.014), subjected to longer time of cardiopulmonary bypass (CPB) (P = 0.032), subjected to postoperative adminstration of epinephrine and dobutamine (P = 0.005), had lower postoperative ejection fraction (P = 0.028), had postoperative myocardial ischemia (P<0.001), had higher serum level of preoperative PAI - 1 (P = 0.0005), higher serum level of postoperative PAI - 1 (P < 0.0001), had larger left atrial diameter > 4 cm (P < 0.0001), had longer length of ICU stay (P = 0.04), and needed postoperative mechanical ventillation P = 0.0026
530			_aIssued also as CD
653		4	_aAtrial fibrillation
653		4	_aInflammation
653		4	_aPlasminogen activator inhibitor
700	0		_aMohamed Ahmed Elbadawy , _eSupervisor
700	0		_aMohamed Fawzy Abdelaleem , _eSupervisor
700	0		_aSuzy Fawzy Michael , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c55480 _d55480