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003 EG-GiCUC
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008 160319s2015 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.10.M.Sc.2015.Am.E
100 0 _aAmira Ramzy Ibrahim Okail
245 1 0 _aEvaluation of vasular changes in morphea patients :
_bA dermoscopy guided immunohistochemical study /
_cAmira Ramzy Ibrahim Okail ; Supervised Manal A. W. Bosseila , Safinaz Salah Eldin Sayed , Marwah Adly Saleh
246 1 5 _aتقييم نمط الأوعية الدموية فى مريض تصلب الجلد المحدد :
_bدراسة بواسطة الديرموسكوب و الكيمياء النسيجية المناعية
260 _aCairo :
_bAmira Ramzy Ibrahim Okail ,
_c2015
300 _a97 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology
520 _aMorphea is a rare autoimmune, inflammatory and fibrosing skin disorder that leads to sclerosis of the dermis and subcutaneous tissue. The underlying pathogenesis of the disease remains unknown, but is likely initiated by vascular injury that terminates in increased collagen production and decreased collagen destruction. Evaluation of vascular changes in morphea patients by dermoscopy and immunohistochemistry. Twenty patients who fulfilled the clinical and histological findings of morphea were included in this study. Patients were subjected to clinical examination, scoring of morphea lesions as well as dermoscopic examination using Dermlite II Hybrid. Two biopsies were taken from each patient: one from the morphea lesion and the second from the non-lesional skin. Paraffin sections were stained by vascular endothelial growth factor (VEGF) to identify blood vessels. Dermoscopic evaluation showed that morphea lesions exhibited a characteristic dermoscopic pattern showing the linear blood vessels with areas of shiny and hypopigmented fibrosis
530 _aIssued also as CD
653 4 _aAngiogenesis
653 4 _aDermoscopy
653 4 _aVascular endothelial growth factor
700 0 _aManal Abdelwahad Bosseila ,
_eSupervisor
700 0 _aMarwah Adly Saleh ,
_eSupervisor
700 0 _aSafinaz Salah Eldin Sayed ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c55616
_d55616