000			03253cam a2200349 a 4500
003			EG-GiCUC
005			20250223031455.0
008			160414s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.27.Ph.D.2015.Na.H
100	0		_aNashwah Samir M. Abdalmoneim Alhariry
245	1	0	_aHistopathologic study and immunohistochemical expression of WT1 protein in different types and grades of astrocytic tumors / _cNashwah Samir M. Abdalmoneim Alhariry ; Supervised Badawia Bayoumy Ibrahim , Mustafa M. Sami Salem , Amal Ahmad M. Hareedy
246	1	5	_aدراسه هستوباثولوجيه والتعبيرالهستوكيميائى المناعى للبروتين دبليوتى1 في مختلف أنواع ودرجات الاورام النجميه
260			_aCairo : _bNashwah Samir M. Abdalmoneim Alhariry , _c2015
300			_a116 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology
520			_aBackground:Wilms{u2019} tumour gene product (WT1) is an embryonic zinc-finger transcription factor, which was originally identified as a tumor suppressor gene and documented as a target for gene therapy of many solid tumors including astrocytic tumors. Aim of work: The aim of this study is the assessment of immunohistochemical expression of WT1 protein, in different histologic types and grades of astrocytic tumors. WT1 protein expression will be correlated with various clinical data (such as age, sex).Material and Methods: The material of this study consisted of 80 paraffin blocks of astrocytoma cases collected from Nasser Institute for Research and Treatment from January 2012 toDecember 2013.Results: WT1 was expressed in (25/28) grade I astrocytomas, all grade II astrocytomas (14/14), (13/16) grade III astrocytomas and (21/22) grade IV with highly significant relationship (P-value<0.001) between grade I and grade IV, grade III and grade IV. Expression was the highest in older ages (significantp-value = 0.034),in male cases (insignificantp-value = 0.298) and in areas of perivascular proliferation and the astrocytic tumors subtypes (gemistocytic astrocytoma, pleomorphic xanthoastrocytoma, protoplasmic astrocytoma and glioblastoma). Conclusion:Many factors affect the expression of WT1 in astrocytomas, rather than the tumor grade, which include tumor vasculature, patient age and the tumor subtype. Recommendations:Further studies are recommended for assessment of WT1 expression in astrocytomas in relation to other brain tumors for detection of its specificity and sensitivity for astrocytic tumors and correlation of WT1 expression with the extent of tumor vasculature and each of astrocytoma histologic subtype and patients{u2019} age.
530			_aIssued also as CD
653		4	_aAstrocytic tumors
653		4	_aAstrocytoma
653		4	_aWT1
700	0		_aAmal Ahmad M. Hareedy , _eSupervisor
700	0		_aBadawiaBayoumy Ibrahim , _eSupervisor
700	0		_aMustafa M. Sami Salem , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAml _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c56015 _d56015