000			03239cam a2200349 a 4500
003			EG-GiCUC
005			20250223031512.0
008			160521s2015 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.06.M.Sc.2015.En.D
100	0		_aEnas Mohamed Elhusseiny Ahmed
245	1	0	_aDetermination of serum human aldehyde dehydrogenase (ALDH) concentration in hepatitis C virus (HCV) infected Egyptian patients with liver cirrhosis and hepatocellular carcinoma / _cEnas Mohamed Elhusseiny Ahmed ; Supervised Abdelgwad Hashem , Aymen Samir Yassin , Amal Ahmed Mohammed
246	1	5	_aٍفى المرضى المصريين الذين يعانون من عدوى فيروس سى الإلتهاب الكبدى الوبائى مع تليف و سرطان الكبد (ALDH) الكشف عن تركيزإنزيم ال
260			_aCairo : _bEnas Mohamed Elhusseiny Ahmed , _c2015
300			_a119 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology
520			_aHepatocellular carcinoma is a primary malignancy of the liver. Hepatocellular carcinoma is now the third leading cause of cancer deaths worldwide, with over 500,000 people affected. In Egypt, hepatocellular carcinoma (HCC) is the second most common cancer in men and the 6th most common cancers in women. This rising incidence and its' poor prognosis make the early detection and surveillance of hepatocellular carcinoma of high importance. Aldehyde dehydrogenase (ALDH) is a polymorphic enzyme responsible for the oxidation of aldehydes to carboxylic acids, which leave the liver and are metabolized by the body{u2019}s muscle and heart. ALDH1 and ALDH2 are the most important enzymes for aldehyde oxidation. These enzymes are found in many tissues of the body but are at the highest concentration in the liver. The aim of this study is to evaluate the diagnostic value of serum Aldehyde dehydrogenase level in hepatitis C virus infected Egyptian patients with cirrhosis and hepatocellular carcinoma. This study included 50 patients with cirrhosis, 50 patients with hepatocellular carcinoma and 37 healthy volunteers. For all groups we studied clinical data, liver function tests, viral markers, serum alpha fetoprotein (AFP) and ALDH concentration using enzyme linked immunosorbent assay (ELISA). Our data showed that ALDH was more sensitive and specific than AFP, ALDH had 74% sensitivity and 82% specificity, P- value (0.000) but AFP had 66% sensitivity and 64% specificity, P - value (0.003). ALDH could be used as useful diagnostic marker for detection of hepatocellular carcinoma and in differentiation between HCC and cirrhosis at a cut off value of 41 U / L
530			_aIssued also as CD
653		4	_aAldehyde dehydrogenase enzyme
653		4	_aHepatitis C virus
653		4	_aHepatocellular carcinoma
700	0		_aAbdelgwad Hashem , _eSupervisor
700	0		_aAmal Ahmed Mohammed , _eSupervisor
700	0		_aAymen Samir Yassin , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c56574 _d56574