000			03596cam a2200349 a 4500
003			EG-GiCUC
005			20250223031514.0
008			160528s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.09.M.Sc.2015.Ma.R
100	0		_aMaha Mohammed Bayoumi Awad
245	1	0	_aRole of furosemide stress test as a novel assessment of tubular function in acute kidney injury / _cMaha Mohammed Bayoumi Awad ; Supervised Hassan M. Khaled , Hamdy Mohamed Saber , Waleed Farouk Mahmoud
246	1	5	_aاستخدام عقار الفروسيميد بالجرعة الاجهادية لتحديد شدة الاصابة بالفشل الكلوى الحاد
260			_aCairo : _bMaha Mohammed Bayoumi Awad , _c2015
300			_a134 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine
520			_aAcute kidney injury is well recognized for its impact on the outcome of patients admitted to the intensive care unit (ICU) . The pursuit of improved biomarkers for the early diagnosis of AKI and its outcomes is an area of intense contemporary research; recent studies have demonstrated the utility of FST dose for predicting the severity of AKI, and possibility of administration as a treatment for AKIN I&II. Our study was conducted on eighty consecutive patients in the general ICU of Nasser institute hospital from July 2014 till July 2015. Forty of our patients received FST dose while the other forty patients received standard management of AKIN I, II. Any patient who develops acute kidney injury grade } - S according to (AKIN) will be subjected to: History taking including (co-morbidity drug intake), clinical examination., Kidney function tests (KFT) daily, estimated glomerular filtration rate GFR, Potassium, magnesium, sodium and phosphorus follow up daily for three days., Hemodynamic monitoring (heart rate HR, mean blood pressure BP, central venous pressure measurement CVP within six hours after inclusion, urine output per hour UOP / 6hour). In first 6 hours, there was a statistically significant increase in urine output in group I after 1st and 2nd hours (P value = 0.026, 0.008 respectively), as well as cumulative UOP over 6 hours (P value = 0.003), as compared to group II, Cut off point as regards UOP for detection of progress to AKINIII and dialysis was found to be 325ml in both group with sensitivity 86.7%, specificity 68% in group I and sensitivity 95%, 95%specificity in group II. There was a highly significant difference between the two groups concerning hypotension with 11 patients in group I vs. none in group II with P value = 0.001, and there was no significance difference between both groups concerning progression to AKIN III and dialysis with P value = 0.260,and there was no significance difference between the two groups concerning length of ICU stay with P value = 0.621, and according to mortality there was no significance difference between the two group with P value = 0.201.UOP in non progressed patients was higher than progressed patients in group I P value 0.001
530			_aIssued also as CD
653		4	_aAKI
653		4	_aDialysis
653		4	_aFurosemide
700	0		_aHamdy Mohamed Saber , _eSupervisor
700	0		_aHassan Mohamed Khaled , _eSupervisor
700	0		_aWaleed Farouk Mahmoud , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c56658 _d56658