000			03211cam a2200361 a 4500
003			EG-GiCUC
005			20250223031517.0
008			160531s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.19.05.Ph.D.2016.Om.I
100	0		_aOmar Shawki Farid Arafah
245	1	0	_aIncidence, Patterns and Effect of Fungal Infections on the Outcome of Patients with Acute Myeloid Leukemia / _cOmar Shawki Farid Arafah ; Supervised Lobna Mohammed Shalaby , Iman Mohamed Zaki , Hadeer Ahmad Elmahalawy
246	1	5	_aمعدل و أنماط العدوى الفطرية و تأثيرها على الناتج النهائي في الأطفال المصابين بسرطان الدم لميلودى الحاد
260			_aCairo : _bOmar Shawki Farid Arafah , _c2016
300			_a199 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
520			_aPatients with hematologic malignancies are at higher risk for invasive fungal infections (IFI) caused by molds than by yeasts, and the incidence of IFI is highest among patients with acute myeloid leukemia. Early detection and may be appropriate antifungal prophylaxis can help to decrease incidence of these infections and its related complications. Patients and methods: A double-arms retrospective and prospective study included 136 newly diagnosed Acute Myeloid Leukemia patients treated at the National Cancer Institute, Cairo university from 2011 to 2013. Prospective group (Group B) received primary Voriconazole and levofloxacin prophylaxis and compared to retrospective control regarding the infectious complications and incidence of fungal infection. Results: Median age was 5 - 6 years. Most patients were males, living in Giza and Cairo. Most patients were standard risk. Age, Gender, initial TLC, initial Monocytic Count, Risk stratifications and previous Hospitalization, were comparable between both groups. Younger age, initial free CT chest and early entry into marrow remission were associated with decreased IFI, while no effect of TLC, Monocytic count and previous Hospitalization. Voriconazole decreased IFI in prospective group significantly. Almost all primary fungal infections occurred in lungs. Most of IFI occurred during induction phase of chemotherapy. Overall survival and Event free survival were comparable between both groups. Three years OS was 38% retrospective and 36% prospective. EFS was 36.6% in pre prophylaxis group compared to 32.5% in prophylaxis group. This is due to high relapses and mortalities. Voriconazole had an accepted toxicity profile
530			_aIssued also as CD
653		4	_aAcute Myeloid Leukemia
653		4	_aInvasive fungal infection
653		4	_aVoriconazole
700	0		_aHadeer Ahmad El-Mahalawy , _eSupervisor
700	0		_aIman Mohamed Zaki , _eSupervisor
700	0		_aLobna Mohammed Shalaby , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAml _eCataloger
905			_aMaha _eRevisor
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c56741 _d56741