000			03259cam a2200349 a 4500
003			EG-GiCUC
005			20250223031518.0
008			160606s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.09.M.Sc.2015.Mi.E
100	0		_aMichael Soliman Megally Meshreky
245	1	0	_aElevated plasma levels of heparin binding protein and hyper lactatemia as predictor of outcome in intensive care unit patients with severe sepsis and septic shock / _cMichael Soliman Megally Meshreky ; Supervised Nashwa Abedalamir , Mohamed Ibrahim Eldesouky , Mohamed Hosni Abdallah
246	1	5	_aارتفاع نسبة البروتين المرتبط بالهيبارين و اللاكتات الشريانى فى الدم كمؤشر للناتج فى حالات الانتان الشديد بالدم و الصدمة الانتانية
260			_aCairo : _bMichael Soliman Megally Meshreky , _c2015
300			_a160 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine
520			_aSevere sepsis and septic shock represent one of the oldest and most pressing problems in medicine. With advances in intensive care, increased awareness, and dissemination of evidence based guidelines, clinicians have taken large strides in reducing the risk of imminent death associated with sepsis. Now days sepsis markers are currently more useful to rule out a diagnosis of sepsis than to actually identify sepsis, but potential new markers are being identified all the time. Heparin binding protein (HBP; also known as azurocidin and CAP37) is a multifunctional inflammatory mediator which is contained within the secretory and azurophilic granulae of human neutrophils and is secreted upon stimulation of the leukocytic membrane-bound Ý2-integrins. This protein is strongly involved in the pathophysiology of severe bacterial infections, and thus represents a potential diagnostic marker and a target for treatment. The present study was designed to evaluate the value of repeated measurements of heparin binding protein serum level in predicting the outcome in critically ill patients diagnosed with severe sepsis and septic shock compared to serum level of C- reactive protein and arterial lactate level. Our study consisted of 20 Egyptian non septic patients and they are considered the control group and randomized 40 Egyptian patients who were admitted to our ICU unit with picture of severe sepsis and septic shock and we have done repeated measurements of serum level of HBP, CRP and arterial lactate to the three groups on admission, on day 2 and day 4 comparing their values in prediction of outcome in severe sepsis and septic shock patients in ICU after 14 days follow up
530			_aIssued also as CD
653		4	_aICU
653		4	_aSeptic shock
653		4	_aSevere sepsis
700	0		_aMohamed Hosni Abdallah , _eSupervisor
700	0		_aMohamed Ibrahim Eldesouky , _eSupervisor
700	0		_aNashwa Abed Alamir , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c56805 _d56805