| 000 | 02474cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031537.0 | ||
| 008 | 160814s2016 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.04.Ph.D.2016.Mo.A | ||
| 100 | 0 | _aMohamed Tawfik Mohamed Nemr | |
| 245 | 1 | 0 |
_aApplication of solid phase technique in the synthesis of certain heterocycles of expected pharmaceutical interest / _cMohamed Tawfik Mohamed Nemr ; Supervised Mohamed Mohsen Ismail , Hanan Mohamed Refaat , Mona Monir Kamel |
| 246 | 1 | 5 | _aتطبيق تقنية الطور الجامد في تشييد مركبات معينة غير متجانسة الحلقة من المتوقع أن يكون لها أهمية |
| 260 |
_aCairo : _bMohamed Tawfik Mohamed Nemr , _c2016 |
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| 300 |
_a185 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry | ||
| 520 | _aThis thesis comprises four chapters. The first chapter is an introduction which includes the solid phase synthesis and biological activity of benzimidazoles, quinoxalines and isoalloxazines. The second chapter clarifies the objectives of the work and schemes designed for the preparation of the target compounds. The third chapter deals with the theoretical discussion of the experimental work, molecular docking and results of cytotoxic activity. The fourth chapter includes the experimental part of the thesis which contains the detailed procedures used for the synthesis of the target compounds and intermediates, in addition to their physical properties, their elemental analyses and spectral data. Moreover, it includes the docking steps of all compounds. The in vitro cytotoxic activity of the synthesized compounds on breast cancer cell line (MCF-7), human hepatic cell line (HEPG2) and human colorectal cell line (HCT116) compared with doxorubicin as a reference anticancer agent is also included in this chapter | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBenzimidazoles | |
| 653 | 4 | _aQuinoxalines | |
| 653 | 4 | _aSolid phase synthesis | |
| 700 | 0 |
_aHanan Mohamed Refaat , _eSupervisor |
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| 700 | 0 |
_aMohamed Mohsen Ismail , _eSupervisor |
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| 700 | 0 |
_aMona Monir Kamel , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamah _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c57438 _d57438 |
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