000			03184cam a2200349 a 4500
003			EG-GiCUC
005			20250223031542.0
008			160904s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.04.M.Sc.2016.Om.R
100	0		_aOmar Mohamed Ismail Marzouk
245	1	0	_aRelation of serum leptin levels and acute coronary syndrome and Its role in the prediction of future cardiovascular events / _cOmar Mohamed Ismail Marzouk ; Supervised Sameh Ahmed Salama , Noha Hassanin Mohamed , Mervat Gaber Elanany
246	1	5	_aالعلاقة بين مستويات اللبتين فى الدم و المتلازمة التاجية الحادة: ودور الليبتين فى التنبؤ بالأحداث القلبية الوعائية المستقبلية
260			_aCairo : _bOmar Mohamed Ismail Marzouk , _c2016
300			_a91P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology
520			_aCoronary artery disease is a major cause of death worldwide. Acute coronary syndrome includes unstable angina, non-ST segment elevation myocardial infarction and ST segment elevation myocardial infarction. By activating immune cells or a direct action on the vascular wall, leptin may affect the initiation and progression of atherosclerosis. We investigated whether plasma leptin concentration is associated with coronary artery disease, with particular focus on the relationship between plasma leptin and the development of an acute coronary syndrome. Plasma leptin was measured in 50 patients with acute coronary syndrome. Their results were compared with those of 50 matched controls. Plasma leptin levels were significantly higher in the acute coronary syndrome group compared to the controls (4.8 vs. 4.5 ng/mL, P = 0.001). These findings suggest that plasma leptin levels may be a useful marker of systemic inflammation, and measurement of plasma leptin may be helpful in assessing the risk of developing coronary heart disease. In patients with acute coronary syndrome, significant elevation of discharge leptin levels compared to admission levels was invariably associated with adverse in-hospital outcome compared to patients who did not experience this outcome (5.93 from 5.88 vs. 4.47 from 5.63 ng/dL, P = 0.032). Elevation of the follow up leptin levels compared to the discharge levels in patients who had short-term cardiovascular events, although was not statistically significant, could also be a risk for having short-term CVEs (4.9 from 4.4 vs. 4.5 from 5.9, P = 0.61). So leptin connotes a poor prognosis with excess morbidity and mortality
530			_aIssued also as CD
653		4	_aAcute coronary syndrome
653		4	_aCoronary artery disease
653		4	_aLeptin
700	0		_aMervat Gaber Elanany , _eSupervisor
700	0		_aNoha Hassanin Mohamed , _eSupervisor
700	0		_aSameh Ahmed Salama , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c57618 _d57618