000			02898cam a2200337 a 4500
003			EG-GiCUC
005			20250223031602.0
008			161023s2016 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.10.M.Sc.2016.Do.U
100	0		_aDoaa Mohamed Abdelmoniem Hassan
245	1	0	_aUtility of enamines as precursors for Synthesis of new heterocycles / _cDoaa Mohamed Abdelmoniem Hassan ; Supervised Said Ahmed Soliman Ghozlan , Ismail Abdelshafy Abdelhamid
246	1	5	_aاستخدام الاينامينات كبادئات اولية لتحضير حلقات غير متجانسة الحلقة جديدة
260			_aCairo : _bDoaa Mohamed Abdelmoniem Hassan , _c2016
300			_a89 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520			_aThe original work of this thesis is composed of three parts. In the first part, a series of N-((1,2,4-triazol-3-yl)-enamine and N-((1,2,3-triazol-4-yl)-enamine were prepared and reacted with Ü,Ý-unsaturated nitriles to yield novel N-(4H-1,2,4-triazol-3-yl)- hexahydroquinoline-3-carbonitrile and their fused and spiro derivatives. Dimroth type rearrangement of the prepared quinoline derivatives was observed in acetic anhydride leading to the formation of substituted pyrimido[4,5-b]quinoline, spiro[indoline-3,5'-pyrimido[4,5- b]quinoline] and spiro[indoline-3,5'-[1,3]oxazino[4,5-b]quinoline] compounds. The second part, A simple and efficient one-pot synthesis of novel thieno[3',2':5,6]pyrimido[1,2- a]quinoline-2-carboxylates and their spirooxindole derivatives were accomplished via the Michael addition reaction of a cyclic Ý-enaminone incorporating thiophene moiety with Ü,Ý- unsaturated nitrile derivatives in EtOH at reflux in the presence of piperidine. Also, novel spirocyclic 2-oxoindole derivatives of thieno[3',2':5,6]pyrimido[1,2-a]quinolone were synthesized by the reaction this cyclic Ý-enaminone with 3-cyanomethylidene 2-oxoindole derivatives in refluxing EtOH. In the third part, The three-component reaction of dimedone, malononitrile dimer and bis-aldehydes in ethanol at reflux in the presence of piperidine afforded bis(5H-chromeno[2,3-b]pyridine-3-carbonitrile) derivatives in excellent yields. The chemical structures of all new synthesized products were confirmed based on the different spectral tools and elemental analysis data
530			_aIssued also as CD
653		4	_aHexahydroquinoline
653		4	_aMichael addition
653		4	_aÝ-Enaminone
700	0		_aIsmail Abdelshafy Abdelhamid , _eSupervisor
700	0		_aSaid Ahmed Soliman Ghozlan , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c58263 _d58263