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003 EG-GiCUC
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008 161101s2016 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.10.10.Ph.D.2016.He.T
100 0 _aHeba Mohamed Ghanem Abdelaziz
245 1 0 _aTrials for production and evaluation of a combined vaccine against fowl cholera and avian Influenza /
_cHeba Mohamed Ghanem Abdelaziz ; Supervised Mona Ibrahim Hassan Elenbaawy , Manal Afifi Aly , Ibrahim Soliman Ibrahim
246 1 5 _aمحاولات لإنتاج و تقيم لقاح مجمع ضد كوليرا الطيور و أنفلونزا الطيور
260 _aCairo :
_bHeba Mohamed Ghanem Abdelaziz ,
_c2016
300 _a188 P. :
_bchart ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Microbiology
520 _aThe study objective was to prepare 2 vaccines of fowl cholera 1st one is bivalent inactivated fowl cholera (P. multocida (5:A, D2) vaccine with montanide ISA70 oil adjuvant (1). 2nd one bivalent inactivated fowl cholera (P. multocida (5: a and D2) vaccine with white oil adjuvant (2). Each vaccine (1) and (2) was vaccinated in a group of chickens (4 weeks old) with dose 0.5 ml S / C, booster dose was given after 1stdose with4 weeks (chicken 8 weeks old) in the 2 groups. Regular withdrawal of blood samples every week. Applying of PHA test on serum collected from 2 groups chicken it was clear that AB titer from vaccine (1) is higher than AB titer in group (2). Applying challenge test on the 2 groups of vaccinated chickens in vaccine (1) protection % for 5: a is 95% and D2 is 90%, while for vaccine (2) 5: a is 90% and D2 is 85%. Depending on these results from the previous experiments, 2 vaccinal batches were prepared using montanide ISA 70 oil adjuvant in the 2 vaccine. 1st one (bivalent inactivated AI vaccine) (3). 2nd one (inactivated combined (AI + FC) vaccine (4). each batch was vaccinated in a group of chicken 4 weeks old, o.5ml S/C one single dose (no booster dose).HI test was applied on serum collected from vaccinated chickens regularly each week. The result showed AB titer for S1 strain is higher than AB titer in S2 Strain in both vaccines. By applying challenge test using local virulent HPAI (H5N1) challenge virus, the protection % in group 3, 93.3% and in group 4, 86.6%
530 _aIssued also as CD
653 4 _aAvian influenza
653 4 _aChickens
653 4 _aFowl cholera
700 0 _aIbrahim Soliman Ibrahim ,
_eSupervisor
700 0 _aManal Afifi Aly ,
_eSupervisor
700 0 _aMona Ibrahim Hassan Elenbaawy ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c58397
_d58397