000			02547cam a2200349 a 4500
003			EG-GiCUC
005			20250223031614.0
008			161115s2016 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2016.Ah.U
100	0		_aAhmed Sherif Abdelraouf Ahmed
245	1	0	_aUrinary neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis / _cAhmed Sherif Abdelraouf Ahmed ; Supervised Hala Salah Eldin Talaat , Miriam Magdy Aziz , Dalia Kadry Ismail
246	1	5	_aان - جى - ايه - ليبوكالين من الدلالات الحيوية فى البول لالتهاب الكلى فى مرض الذئبة الحمراء لدى الأطفال
260			_aCairo : _bAhmed Sherif Abdelraouf Ahmed , _c2016
300			_a105 P. ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aMore than 60% of children with systemic lupus erythematosus (SLE) develop lupus nephritis (LN). Neutrophil gelatinase associated lipocalin (NGAL) is a protein secreted by leukocytes during inflammation and is overexpressed in the kidneys following ischemic and nephrotoxic damage. To evaluate the role of urinary neutrophil gelatinase associated lipocalin-2 as a biomarker of renal involvement in SLE patients. Urinary levels of NGAL were assessed in 50 children with active SLE (25 with and 25 without LN) and compared to 25 matched controls. Children with SLE had elevated urinary NGAL (±295.8 ng / ml) as compared to controls (±124.4 ng / ml) (P < 0.001). Levels of urinary NGAL were higher in patients with LN (±822.8ng / ml) than those without LN (±295.8 ng / ml) (P < 0.001). In patients with LN, urinary levels of NGAL were correlated with the quantitative and qualitative measures of proteinuria (P < 0.001). Urinary NGAL was not significantly correlated with the histopathological classification by renal biopsy (P < 0.292). Urinary NGAL is a sensitive marker of proliferative nephritis in juvenile SLE
530			_aIssued also as CD
653		4	_aLipocalin 2
653		4	_aProliferative lupus nephritis
653		4	_aUrinary NGAL
700	0		_aDalia Kadry Ismail , _eSupervisor
700	0		_aHala Salah Eldin Talaat , _eSupervisor
700	0		_aMiriam Magdy Aziz , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c58620 _d58620