000 02528cam a2200349 a 4500
003 EG-GiCUC
005 20250223031643.0
008 170123s2016 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.08.08.Ph.D.2016.Ma.P
100 0 _aManal Medhat Ahmed Ali Eneibar
245 1 2 _aA pharmaceutical study on modified dosage forms of a certain anti migraine drug /
_cManal Medhat Ahmed Ali Eneibar ; Supervised Samia H. Shalaby , Mohamed A. Elnabarawi , Aly A. Abdelbary
246 1 5 _aدراسة صيدلية فى أشكال متحورة على عقار معين لعلاج الصداع النصفى
260 _aCairo :
_bManal Medhat Ahmed Ali Eneibar ,
_c2016
300 _a226 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520 _aMigraine is a common, chronic disorder. Clinically, migraine is characterized by recurrent attacks of headache followed by neurological and visual disturbances. Migraine greatly affects quality of life. WHO ranks migraine among the world{u2019}s most disabling medical illness. Sublingual administration is intended where the dosage form is placed under the tongue aiming for the drug to reach directly into the blood stream through the ventral surface of the tongue and floor of the mouth. The sublingual route usually produces a faster onset of action than orally ingested drug and the portion absorbed through the sublingual vessels bypasses the hepatic first pass metabolism and thus produces acceptable bioavailability. The absorption of the drug through the sublingual route is 3 to 10 times greater than the oral route. Sublingual dosage forms can be divided into sublingual tablets, sublingual films and sublingual sprays. Sublingual tablets are usually small tablets that must dissolve or disintegrate quickly in small volume of saliva to allow the drug to be absorbed quickly. They can be divided into fast disintegrating sublingual tablets and bioadhesive sublingual tablets
530 _aIssued also as CD
653 4 _aAnti migraine drug
653 4 _aHeadache
653 4 _aModified dosage forms
700 0 _aAly Ahmed Abdelbary ,
_eSupervisor
700 0 _aMohamed Ahmed Elnabarawi ,
_eSupervisor
700 0 _aSamia Hassan Shalaby ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c59579
_d59579