000 01774cam a2200325 a 4500
003 EG-GiCUC
005 20250223031645.0
008 170204s2016 ua f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.10.M.Sc.2016.Ma.S
100 0 _aMarwa Soliman Gaman Salama
245 1 0 _aSynthesis and anti tumor evaluation of Heterocyclic compounds synthesized from Ý-diketone and active methylene derivatives /
_cMarwa Soliman Gaman Salama ; Supervised Rafat Milad Mohareb
246 1 5 _aتحضير و قياس مضادات الأورام لمركبات غير متجانسة الحلقة محضرة من مشتقات البيتا ثنائى الكيتون و الميثيلين النشطة
260 _aCairo :
_bMarwa Soliman Gaman Salama ,
_c2016
300 _a120 P. ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520 _aIn this work the reaction of O-phenylenediamine (1) with diethylmalonate (2) in an oil bath at 120 {u00B0}C gave ethyl 2- (1H-benzo [d] imidazol-2-yl) acetate (3). Compound 3 was used in many acyclic and heterocyclic reactions. The latter products underwent a series of heterocyclization reactions to yield pyrazole, thiophene, pyridine and coumarin derivatives. The antitumor evaluations of the newly synthesized products against three cancer cell lines were measured
530 _aIssued also as CD
653 4 _aBenzimidazole compounds
653 4 _aHeterocycles
653 4 _aSynthesis
700 0 _aRafat Milad Mohareb ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c59670
_d59670