000 02518cam a2200337 a 4500
003 EG-GiCUC
005 20250223031656.0
008 170301s2016 ua f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.10.M.Sc.2016.Am.S
100 0 _aAmna Mohamed Abdella Ali
245 1 0 _aSynthesis of bis (difunctional) compounds as versatile precursors for Novel Bis heterocycles /
_cAmna Mohamed Abdella Ali ; Supervised Ahmed Helmy Mahmoud Elwahy , Ismail Abdelshafy Abdelhamid
246 1 5 _aتشييد مركبات ثنائية و متماثلة (ثنائية المجموعة الوظيفية) كبادئات خصبة لمركبات حلقية غير متجانسة جديدة ثنائية و متماثلة
260 _aCairo :
_bAmna Mohamed Abdella Ali ,
_c2016
300 _a90 P. ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520 _aAn efficient and convenient method for the synthesis of bis (4H-chromene-3-carbonitrile) derivatives. The synthetic pathway involves one pot, multi-component reaction of bis- aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine. A stepwise approach for the synthesis of the target compounds was also investigated. Bis (2- benzylidene-1H-indene)-1,3-(2H)-dione derivatives were obtained as the main products as a result of reaction of the bis(arylidenemalononitriles) with indandione. The anti-influenza H5N1 virus activities of the newly prepared bis-chromene derivatives are also investigated. An efficient and convenient route for the synthesis of novel bis dihydropyrano[3,2- c]chromenes is reported. The synthetic pathway involves one pot, multi-component reaction of bis-aldehydes, malononitrile, and 4-hydroxycoumarin in the presence of pyridine or acetic acid in the presence of sodium acetate. A stepwise approach for the synthesis of the target compounds was also investigated. The structures of all compounds are confirmed based on the different spectral tools
530 _aIssued also as CD
653 4 _aBis-arylaldehydes
653 4 _abis-arylidenemalononitriles
653 4 _aMulticomponent reactions
700 0 _aAhmed Helmy Mahmoud Elwahy ,
_eSupervisor
700 0 _aIsmail Abdelshafy Abdelhamid ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c60038
_d60038