000			03284cam a2200349 a 4500
003			EG-GiCUC
005			20250223031702.0
008			170312s2016 ua o f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.08.M.Sc.2016.Sa.C
100	0		_aSahar Atef Azmy Alshabasy
245	1	0	_aComparative study of different digoxin treatment regimens in Egyptian hospitals / _cSahar Atef Azmy Alshabasy ; Supervised Samar Farid , Maggie Abbassi , Mohamed Selim
246	1	5	_aدرا{uئإآ٤}{uئإإء} {uئإؤئ}{uئإإ٤}{uئإؤ٨}{uئإ٨إ}ر{uئإإ٨}{uئإ٩٤} أ{uئإإ٨}ظ{uئإإ٤}{uئإإء} {uئإأآ}{uئإئأ}{uئإء٠}{uئإئ٤}{uئإ٩٤} {uئإإ٤}{uئإء٨}{uئإ٩٨}{uئإإ٠}{uئإؤ٤}{uئإ٩٤} {uئإؤئ}{uئإإ٠}د{uئإئ٤}{uئإء٠}و{uئإؤآ}{uئإآ٤}{uئإئ٤}ن فى ا{uئإؤئ}{uئإإ٤}{uئإآ٤}{uئإ٩٨}{uئإآ٨}{uئإؤ٤}{uئإئ٤}{uئإ٨إ}ت ا{uئإؤئ}{uئإإ٤}{uئإآأ}ر{uئإئ٤}{uئإ٩٤}
260			_aCairo : _bSahar Atef Azmy Alshabasy , _c2016
300			_a80 P. : _bphotographs ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aDigoxin is a cardiac glycoside prescribed in heart failure and atrial fibrillation. It exerts positive inotropic, neurohormonal and electrophysiological actions on the heart. Because of inter and intra-patient variability, narrow therapeutic index, and risk of toxicity, digoxin doses are calculated based on the patient weight, renal status, indications and drug interactions. In Egypt most cardiologists give digoxin holiday (the drug is off for one or two days a week) for both atrial fibrillation and heart failure to avoid possible drug accumulation and toxicity. It is not clear if these interrupted digoxin regimens really offer safer alternative over the continuous dosing regimens without compromising the effectiveness and patient quality of life. It is anticipated that plasma digoxin levels may fall below the therapeutic range during the holiday which may affect patient clinical status. To evaluate and compare the digoxin serum concentration and patient{u2019}s quality of life in the continuous versus interrupted digoxin dosing regimens. Patients were randomized to receive one of four regimens: regimen 1: one tablet (0.25mg) daily except Friday (N=17); regimen 2: one tablet (0.25mg) daily except Thursday and Friday (N=17); regimen 3: half tablet (0.125mg) daily (N=17); and regimen 4: a tailored dose was calculated based on patient{u2019}s renal function and given daily (N=23). After reaching steady state in the two holiday regimens, two plasma samples were collected (preholiday and post holiday trough concentrations); in the other two groups one trough plasma sample was collected
530			_aIssued also as CD
653		4	_aAtrial fibrillation
653		4	_aDigoxin
653		4	_aInterrupted regimens
700	0		_aMaggie Abbassi , _eSupervisor
700	0		_aMohamed Selim , _eSupervisor
700	0		_aSamar Farid , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c60231 _d60231