000			03161cam a2200349 a 4500
003			EG-GiCUC
005			20250223031711.0
008			170403s2012 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.18.M.Sc.2012.Mo.C
100	0		_aMohamed Khairy Mohamed
245	1	0	_aCreatinine, cystatin and combined-based equations in assessment of renal functions in type 2 diabetic Egyptian patients / _cMohamed Khairy Mohamed ; Supervised Hatem Abdelhamid Darwish , Ahmed Abdelsamie , Mahmoud Mohamed Elnokeety
246	1	5	_aالمقارنة بين المعادلات القائمة على استخدام مادة (الكرياتينين): مادة (السيستاتين - سى) او كليهما معا فى تقييم وظائف الكلى لمرضى السكرى النوع الثانى فى مصر
260			_aCairo : _bMohamed Khairy Mohamed , _c2012
300			_a145 P. : _bfacsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520			_aDiabetic nephropathy is the principal single cause of end-stage renal disease (ESRD). The most important parameter in the clinical evaluation of kidney function is the glomerular filtration rate (GFR), which is generally accepted as the best overall index of kidney function, GFR remains the corner stone of the clinical evaluation of overall kidney function (emilio R, et al. 2007). Over many studies, researchers tried to figure out the most suitable GFR marker regarding accuracy, simplicity, economicity and finally to be expressive to degree of renal damage, our study tries to cope with such precise goal. Our study was performed to compare between eGFR equations based on serum creatinine and/or cystatin C performance in relation to measured GFR using radionuclide study and degree of proteinuria. In our cross sectional study, eighty adult type 2 diabetic patients, with overt diabetic nephropathy and proteinuria more than 300 mg/24 hours, were included after application of inclusion and exclusion criteria, and subjected to history taking, clinical examination and laboratory investigation including serum creatinine, cystatin-C, 24h urinary proteins/creatinine clearance and renal isotopes Tc-DPTA scanning. Our result showed a linear correlation between serum creatinine and cystatin c (r=0.867 and P=0.000). Cystatin C was better correlated (r -0.781, p 0.000) with isotopically measured GFR than creatinine (r- 0.106, p 0.348). Also the performance of cystatin C was better than creatinine in all eGFR equation tested in our study MDRD, CKD-Epi cr 2009, CKD-Epi cr-Cys 2012, CKD-Epi Cys2012
530			_aIssued also as CD
653		4	_aDiabetic nephropathy
653		4	_aGlomerular filtration rate
653		4	_aType 2 diabetes
700	0		_aAhmed Abdelsamie , _eSupervisor
700	0		_aHatem Abdelhamid Darwish , _eSupervisor
700	0		_aMahmoud Mohamed Elnokeety , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c60510 _d60510