000			03142cam a2200349 a 4500
003			EG-GiCUC
005			20250223031721.0
008			170509s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2016.Ra.E
100	0		_aRawdhah Ahmed Abdulrahman
245	1	0	_aEvaluation of renal tubular injury in Egyptian patients with cystic fibrosis / _cRawdhah Ahmed Abdulrahman ; Supervised Mona Mohsen Elattar , Walaa AboulKasem Ismail Shahin , Walaa Ahmed Rabie
246	1	5	_aتقييم اذية الانابيب الكلوية عند الاطفال المصريين المصابون بمرض التليف الحويصلى
260			_aCairo : _bRawdhah Ahmed Abdulrahman , _c2016
300			_a102 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aCystic fibrosis is the most common life-limiting autosomal recessive disease among people in the USA and europe with increased prevalence in Egypt. Pulmonary disease is the most important cause of morbidity and mortality in CF. Affected children are also in danger of acute kidney injury and the development of chronic renal disease due to presence of CFTR gene in renal tubules as well as exposure to multiple potentially nephrotoxic agents including aminoglycosides, non-steroidal anti-inflammatory drugs NSAIDs and immune-suppressants. The aim of our study is to early detection of renal impairment in Egyptian patients with CF and hence careful monitoring and adjustment of medications especially nephrotoxic drugs like garamycin, Amikacin and Ciprofloxacin which are used repeatedly in these patients. Fifty CF patients were enrolled in our study from the allergy and pulmonology unit in children hospital of Cairo university. Diagnosed based on clinical manifestations and elevated sweat chloride testing{u2265}60mg/L. They were age and sex matched to forty healthy children as a control group. All patients are screened for renal affection by measuring urine analysis, kidney function tests, FENa, Ý2MG, KIM-1 in urine using ELISA technique and renal U/S. Out of 50 children there are 30 patients (60%) have high levels of Ý2MG and 33 patients (66%) have high levels of KIM-1. There were significant differences between Ý2MG enzyme level and KIM-1 enzyme level in case and control children (P value<0.05). Serum creatinine and renal U/S were normal for all patients. There was significant Correlation between urinary Ý2MG, KIM-1 enzymes elevation and duration of disease P value<0.01, P value<0.01 respectively
530			_aIssued also as CD
653		4	_aCystic fibrosis
653		4	_aUrinary kidney injury molecule-1 enzyme
653		4	_aUrinary Ý2{u2013}micro globulin
700	0		_aMona Mohsen Elattar , _eSupervisor
700	0		_aWalaa AboulKasem Ismail Shahin , _eSupervisor
700	0		_aWalaa Ahmed Rabie , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c60842 _d60842