000			02852cam a2200349 a 4500
003			EG-GiCUC
005			20250223031722.0
008			170509s2016 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2016.Di.T
100	0		_aDina Aly Abdelhay
245	1	0	_aTroponin as an early marker for detection of cardiomyopathy in beta-thalassemia patients / _cDina Aly Abdelhay ; Supervised Mona Hassan Eltagui , Marwa Farouk Mira , Heba Nabil Baz
246	1	5	_aقياس نسبة انزيم التروبونين كعالمة مبكرة على اعتالل عضلة القلب فى مرضى انيميا البحر المتوسط
260			_aCairo : _bDina Aly Abdelhay , _c2016
300			_a119 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aHeart disease remains the major cause of morbidity and mortality in thalassemic patients. Multiple pathologies have been suggested in the development of cardiac dysfunction in thalassemic patients including: iron overload in the heart, leading to RV diastolic then LV systolic dysfunction, chronic anemia and the tissue hypoxia it induces together with impair free fatty acid oxidation and ATP production in myocardial cells. Because congestive heart failure is the main cause of death in these patients, early recognition of cardiac dysfunction may be useful in modifying the therapy. Tissue doppler echocardiography and serum troponin level may be a promising tool for such a purpose. Thirty thalassemic patients with a mean age of 12.93±2.07 years and thirty aged matched healthy control subjects have been included in the study. Patients have been recruited from pediatric hematology clinics in both Cairo university. Conventional, TDI as well as conventional and M-Mode echogardiography was performed to all patients and control subjects in addition to myocardial relaxometry T2* by cardiac MRI and serum assays of troponin. Though no statistically significant difference was noted between cases and controls by conventional echocardiographic parameters, compared to normal subjects, we found by tissue doppler imaging that there is significant difference of Rv e'/a' ratio between cardiac and non-cardiac iron overloaded patients which reflects early diastolic dysfunction in cardiac iron overloaded patients
530			_aIssued also as CD
653		4	_aIron load
653		4	_aMyocardial affection
653		4	_aThalassemia
700	0		_aHeba Nabil Baz , _eSupervisor
700	0		_aMarwa Farouk Mira , _eSupervisor
700	0		_aMona Hassan Eltagui , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c60854 _d60854