000			03280cam a2200337 a 4500
003			EG-GiCUC
005			20250223031731.0
008			170611s2016 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.08.Ph.D.2016.Ma.P
100	0		_aMarian Joseph Naguib
245	1	2	_aA pharmaceutical study on a central nervous system acting drug for intranasal administration / _cMarian Joseph Naguib ; Supervised Samia A. Nour , Nevine S. Abdelmalak
246	1	5	_aدراسة صيدلية على توصيل عقار يعمل على الجهاز العصبى المركزى عن طريق الانف
260			_aCairo : _bMarian Joseph Naguib , _c2016
300			_a169 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aThis study aimed to formulate clonazepam (CZ) as intranasal nanocarriers for immediate control of status epilepticus. Nanocarriers generally have the ability to deliver the drug to the brain through olfactory and trigeminal nerves pathways circumventing the blood brain barrier. Chapter I: Formulation of clonazepam loaded polymeric micelles. A three-level three-factor central composite face-centered design (3³ CCFD) was applied for the preparation using thin film hydration technique. The independent variables were; pluronic® P123 concentration (X₁), Pluronics®: drug ratio (X₂) and hydration volume (X₃). The seventeen prepared formulae were evaluated for: Y₁: entrapment efficiency (%), Y₂: particle size (nm), Y₃: polydispersity index , Y₄: zeta potential (mV), Y₅: cumulative clonazepam released after eight hours (%), Y₆: time for the release of 50% of drug (hr) and Y₇: dissolution efficiency. All the responses except particle size and zeta potential were influenced by the studied variables. Optimization was done by maximizing entrapment efficiency, amount released after eight hours and dissolution efficiency and minimizing polydispersity index and time for the release of 50% drug. The highest desirability value obtained was 0.921 and was denoted to: X₁=50%, X₂=40:1 and X₃=10 ml (formula PM7). Differential scanning calorimetery and transmission electron microscopy demonstrated the ability of the optimized formula to incorporate clonazepam. This formula showed good thermodynamic and kinetic stability when stored for 4 weeks at room temperature. Chapter II: Formulation of clonazepam loaded Transferosomes. Full factorial design (FFD) (2² X 3¹) was adopted for the preparation using thin film hydration technique. The independent variables investigated were X₁: edge activator type (sodium deoxycholate and Labrafil®), X₂: lipid: edge activator molar ratio 10:1, 30:1 and 50:1 and X₃: initial drug amount 10 and 20 mg
530			_aIssued also as CD
653		4	_aCentral nervous system acting
653		4	_aFormulate clonazepam (CZ)
653		4	_aIntranasal administration
700	0		_aNevine Shawky Abdelmalak , _eSupervisor
700	0		_aSamia Abdelkader Nour , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c61177 _d61177