000			02769cam a2200349 a 4500
003			EG-GiCUC
005			20250223031737.0
008			170620s2016 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2016.So.F
100	0		_aSoliman Adel Soliman Al Safoury
245	1	0	_aFollicular fluid oxidative stress as a marker for pregnancy rate and its relation to obesity in human females / _cSoliman Adel Soliman Alsafoury ; Supervised Abdelwahab AboBaker Alghareeb , Fatma Alzahraa Hussien , Eman Kamal Shaeer
246	1	5	_aالإجهاد التأكسدى للسائل الحويصلى كدلالة على معدل الحمل و علاقته بالسمنة عند السيدات
260			_aCairo : _bSoliman Adel Soliman Alsafoury , _c2016
300			_a88 P. ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aObjective: To study the in{uFB02}uence of female obesity on follicular {uFB02}uid oxidative stress and to correlate it to intracytoplasmic sperm injection (ICSI) outcome. Study design: Seventy-four normal females below the age of 40 undergoing ICSI for reason of male factor infertility were enrolled in the study. They were divided into 2 groups according to body mass index (BMI); Group I (non-obese) (n=24, BMI <25Kg/m2) and Group II (obese) (n=50, BMI P 25Kg/m2). Oxidative stress markers (MDA (malonaldehyde), NO2/NO3 (Nitrite/Nitrate) ratio, GSH (reduced glutathione) and GSH/GSSG (reduced glutathione/oxidized glutathione) ratio) were measured by high performance liquid chromatography (HPLC). Results: Obese women had signi{uFB01}cantly higher mean follicular {uFB02}uid MDA (P=0.006) as well as NO2/NO3 ratio (P = 0.004). BMI strongly correlated to follicular {uFB02}uid MDA (P=<0.01). MDA showed strong positive correlation to NO2/NO3 ratio (P=0.02). GSH and GSH/GSSG ratio showed a non- signi{uFB01}cant difference between the two groups (P=0.14 and 0.67, respectively). Clinical pregnancy rate was signi{uFB01}cantly higher in the non-obese group (87%) compared to the obese (43%) (P=<0.01, OR:13; 95% CI 3.54-52). With binary logistic regression, MDA was found to be a good predictor of the occurrence of pregnancy (P=<0.01). No signi{uFB01}cant differences were
530			_aIssued also as CD
653		4	_aICSI
653		4	_aObesity
653		4	_aOxidative stress
700	0		_aAbdelwahab AboBaker Alghareeb , _eSupervisor
700	0		_aEman Kamal Shaeer , _eSupervisor
700	0		_aFatma Alzahraa Hussien , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c61370 _d61370