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003 EG-GiCUC
005 20250223031809.0
008 170919s2017 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.08.04.Ph.D.2017.De.D
100 0 _aDemiana Samir Mikhail
245 1 0 _aDesign and synthesis of some pyridazine containing compounds of expected anticancer activity /
_cDemiana Samir Mikhail ; Supervised Salwa Elsayed Mohamed Elmeligie , Eman Mohamed Ahmed , Suzan Mohamed Abuelmaaty
246 1 5 _a{uFE97}{uFEBC}{uFEE4}{uFBFF}{uFEE2} و {uئإ٩٧}{uئإآ٨}{uئإئ٤}{uئآئئ}{uئإءء} {uئإ٩١}{uئإأأ}{uئإآإ} المر{uئإؤآ}{uئإ٩٢}{uئإ٨إ}ت {uئإ٨ؤ}{uئإؤئ}{uئإ٩٨}{uئإئ٠} {uئإ٩٧}{uئإء٤}{uئإ٩٨}{uئإإإ}{uئإإئ} {uئإأآ}{uئإإ٠}{uئإئ٠} {uئإء٣}{uئإإ٠}{uئإؤ٨}{uئإ٩٤} {uئإ٨ؤ}{uئإؤئ}{uئإ٩٢}{uئآئئ}{uئإءإ}{uئآئإ}{uئإءء}از{uئآئإ}{uئإإ٦} {uئإإؤ} {uئإ٨ؤ}{uئإؤئ}{uئإإ٤}{uئإ٩٨}{uئإإإ}{uئإؤ٧}{uئإأء} {uئإؤئ}{uئإإأ}{uئإ٨إ} {uئإ٩٧}{uئإ٨٤}{uئإ٩آ}{uئآئئ}{uئإءإ} {uئإإ٣}{uئإأ٠}{uئإ٨إ}{uئإء٩} {uئإؤئ}{uئإإ٠}{uئإآ٤}{uئإءإ}ط{uئإ٨إ}ن
260 _aCairo :
_bDemiana Samir Mikhail ,
_c2017
300 _a142 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry
520 _aThis study comprises a brief literature survey on cancer, its causes and treatment as well as biological activities and chemistry of pyridazine and fused pyridazine derivatives. The thesis involves design of some new pyridazine and fused pyridazine derivatives aiming to possess an anticancer activity through inhibition of VEGFR. The Schemes followed for the preparation of the designed compounds are summarized asfollows: Scheme (1) starts with the preparation of the root compound N-carbamimidoyl-4-[(6-chloropyridazin-3-yl) amino]benzenesulphonamide (I) followed by reaction with different aromatic amines to give N-Carbamimidoyl-4- [(6-arylaminopyridazin-3-yl)amino]benzenesulphonamides IIa-f. Scheme (2) involves nucleophilic substitution reaction of compound I with meta and para phenylenediamine to give the relevant compounds IIIa, b. Furthermore, compound IIIa was reacted with each of acetyl chloride and 3-chloropropionyl chloride to give the corresponding pyridazine derivatives IVa, b respectively. Further, compounds IIIa, b were reacted with different alkyl isothiocyanates to give the corresponding thiourea compounds Va-d and VIa-d. On the other hand, scheme (3A) involves the reaction of compound I with each of 2-aminophenol, different substituted anthranilic acids and 2-aminonicotinic acid to give the corresponding pyridazino [1,6-a] benzimidazole VII, pyridazino [6,1-b] quinazolines VIIIa,c,d and pyrido [2{u2019}, 3{u2019},4,5] pyrimido [1,2- b]pyridazine VIIIb respectively
530 _aIssued also as CD
653 4 _aAnticancer activity
653 4 _aCancer
653 4 _aPyridazine
700 0 _aEman Mohamed Ahmed ,
_eSupervisor
700 0 _aSalwa Elsayed Mohamed Elmeligie ,
_eSupervisor
700 0 _aSuzan Mohamed Abuelmaaty ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c62405
_d62405