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| 003 | EG-GiCUC | ||
| 005 | 20250223031809.0 | ||
| 008 | 170919s2017 ua f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.04.Ph.D.2017.Ya.D | ||
| 100 | 0 | _aYara Sayed Mahmoud Eldash | |
| 245 | 1 | 0 |
_aDesign, synthesis and evaluation of fused pyrimidine derivatives as potential anticancer agents / _cYara Sayed Mahmoud Eldash ; Supervised Samir Botros Salib , Omneya Mahmoud Khalil , Mona Mounir Kamel |
| 246 | 1 | 5 | _a{uFE97}{uFEBC}{uFEE4}{uFBFF}{uFEE2} و {uئإ٩٧}{uئإآ٨}{uئآئئ}{uئآئئ}{uئإءء} و {uئإ٩٧}{uئإؤ٨}{uئآئئ}{uئآئئ}{uئإإ٢} {uئإإ٣}{uئإآ٨}{uئإ٩٨}{uئإؤ٨}{uئإ٨إ}ت {uئإء٣}{uئإإ٠}{uئإؤ٨}{uئإ٩٤} ا{uئإؤئ}{uئإ٩٢}{uئآئئ}{uئإءإ}{uئآئإ}{uئإإ٤}{uئآئئ}{uئإءء}{uئآئإ}{uئإإ٦} ا{uئإؤئ}{uئإإ٤}{uئإإ٠}{uئإ٩٨}{uئإء٤}{uئإإ٤}{uئإ٩٤} {uئإؤآ}{uئإإ٤}{uئإأ٠}{uئإ٨إ}دات {uئإؤئ}{uئإإ٠}{uئإآ٤}{uئإءإ}ط{uئإ٨إ}ن |
| 260 |
_aCairo : _bYara Sayed Mahmoud Eldash , _c2017 |
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| 300 |
_a274 P. ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry | ||
| 520 | _aThe present Thesis comprises six chapters and aims at the synthesis and evaluation of the anticancer activity of a number of tetrahydrobenzothieno [2,3-d] pyrimidines as well as tetrahydrobenzothieno [3,2-e][1,2,4] triazolo [4,3-a] pyrimidine derivatives. Chapter I is an introduction which consists of a brief literature survey on the recent approaches in the synthesis of thieno[2,3-d]pyrimidine derivatives and 1,2,4-triazolo[4,3-a]pyrimidines in addition to an account on their cytotoxic activity. Moreover, a brief account on matrix metalloproteinase inhibitors and their fundamental interactions with MMP binding sites is included. Chapter II presents the aim of the work together with illustration of the schemes carried out to obtain the new thieno [2,3-d]pyrimidine derivatives. Chapter III explains the theoretical discussion of the experimental work used for the synthesis of the newly synthesized compounds (schemes A-H) and spectroscopic confirmation of the intermediates and the target compounds. Scheme A is concerned with the preparation of the starting compound; ethyl 2- amino-4,5,6,7-tetrahydro[1] benzothiophene-3-carboxylate (I). Reaction of I with benzyl isothiocyanate yielded the key intermediate 3-benzyl-2-sulphanyl-5,6,7,8- tetrahydro-4-oxo(3H)-[1]benzothieno[2,3-d]pyrimidine (II). Alkylation of the 2- sulfanylthienopyrimidine II was carried out using different solvent/ base systems in order to obtain a series of S-alkylated derivatives VIa-d, VIIa-c and VIIIa-c which differ in the linker skeleton as well as the bioactive amine | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _a1,2,4-triazolothienopyrimidines | |
| 653 | 4 | _aAnticancer activity | |
| 653 | 4 | _aThieno [2,3-d]pyrimidines | |
| 700 | 0 |
_aMona Mounir Kamel , _eSupervisor |
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| 700 | 0 |
_aOmneya Mahmoud Khalil , _eSupervisor |
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| 700 | 0 |
_aSamir Botros Salib , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c62417 _d62417 |
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