000			03025cam a2200349 a 4500
003			EG-GiCUC
005			20250223031813.0
008			170926s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.27.M.Sc.2016.Ab.R
100	0		_aAbdulhakeem Ibrahim Abdulhakeem
245	1	0	_aRole of cyclin D1 in inflammatory bowel disease : _bHistopathological and immunohistochemical study / _cAbdulhakeem Ibrahim Abdulhakeem ; Supervised Bahaa Ihab Mounir , Dina Omar Helmy , Lubna Omar Elfarouk Abdelsalam
246	1	5	_aدور سيكلين د-1 فى مرض التهاب الأمعاء : _bدراسة نسيجية مناعية و كيميائية
260			_aCairo : _bAbdulhakeem Ibrahim Abdulhakeem , _c2016
300			_a119 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology
520			_aBackground: Inflammatory bowel disease (IBD) is one of the important causes of chronic diarrhea that shows an increasing incidence in the world especially in the middle east. Cell cycle progression is facilitated by CDKs that are activated by cyclins, including cyclin D1. Evidence of the involvement of cyclin gene alterations and overexpression in human cancer is growing. Aim of Work: This work aimed to examine immunohistochemical (I.H.C.) expression of cyclin D1 in inflammatory bowel disease and its correlation with the age, sex, disease activity, dysplasia and clinical presentation of the disease as we try to find a relation between the cyclin D1 expression on one hand with the disease activity and dysplasia in the other hand. Methods: This study consisted of 40 cases of IBD; 35 cases were ulcerative colitis and 5 cases were crohn{u2019}s disease retrieved as routinely processed paraffin blocks taken from the department of pathology, Kasr Elainy hospital in addition to some private labs. For all specimens, the clinical data were available on the computer files including age and sex of the patients as well as their clinical presentation. Microscopic examination of the H and E stained slides was done to assess the degree of disease activity (and dysplasia if present) for each slide. The activity of IBD was assessed depending on degree of inflammation, percentage of cryptitis, erosions and ulcerations. I.H.C. reactions were carried out by using cyclin D1 monoclonal antibody. Immunohistochemical expression of cyclin D1 was estimated by evaluating the intensity of brown nuclear staining of intestinal epithelial cells
530			_aIssued also as CD
653		4	_aCDKs
653		4	_aCyclin D1
653		4	_aInflammatory bowel disease
700	0		_aBahaa Ihab Mounir , _eSupervisor
700	0		_aDina Omar Helmy , _eSupervisor
700	0		_aLubna Omar Elfarouk Abdelsalam , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c62568 _d62568